The spared nerve injury model of neuropathic pain.

Détails

ID Serval
serval:BIB_9C4D7EAA2EE9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The spared nerve injury model of neuropathic pain.
Périodique
Methods In Molecular Biology
Auteur(s)
Pertin M., Gosselin R.D., Decosterd I.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2012
Volume
851
Pages
205-212
Langue
anglais
Notes
Publication types: Journal Article
Résumé
The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.
Mots-clé
Animals, Disease Models, Animal, Mice, Neuralgia/etiology, Neuralgia/pathology, Pain Threshold, Peripheral Nerve Injuries/complications, Peripheral Nerve Injuries/pathology, Rats, Rats, Sprague-Dawley
Pubmed
Web of science
Création de la notice
23/05/2012 11:07
Dernière modification de la notice
03/03/2018 19:56
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