Evolution of source EEG synchronization in early Alzheimer's disease.

Détails

ID Serval
serval:BIB_9C0D546A0FA3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolution of source EEG synchronization in early Alzheimer's disease.
Périodique
Neurobiology of Aging
Auteur(s)
Knyazeva M.G., Carmeli C., Khadivi A., Ghika J., Meuli R., Frackowiak R.S.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
2013
Volume
34
Numéro
3
Pages
694-705
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Alzheimer's disease (AD) disrupts functional connectivity in distributed cortical networks. We analyzed changes in the S-estimator, a measure of multivariate intraregional synchronization, in electroencephalogram (EEG) source space in 15 mild AD patients versus 15 age-matched controls to evaluate its potential as a marker of AD progression. All participants underwent 2 clinical evaluations and 2 EEG recording sessions on diagnosis and after a year. The main effect of AD was hyposynchronization in the medial temporal and frontal regions and relative hypersynchronization in posterior cingulate, precuneus, cuneus, and parietotemporal cortices. However, the S-estimator did not change over time in either group. This result motivated an analysis of rapidly progressing AD versus slow-progressing patients. Rapidly progressing AD patients showed a significant reduction in synchronization with time, manifest in left frontotemporal cortex. Thus, the evolution of source EEG synchronization over time is correlated with the rate of disease progression and should be considered as a cost-effective AD biomarker.
Pubmed
Web of science
Création de la notice
26/12/2012 13:46
Dernière modification de la notice
20/08/2019 15:02
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