Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease.

Détails

ID Serval
serval:BIB_9C07CE4634D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease.
Périodique
Journal of Psychiatric Research
Auteur(s)
Popp J., Bacher M., Kölsch H., Noelker C., Deuster O., Dodel R., Jessen F.
ISSN
1879-1379 (Electronic)
ISSN-L
0022-3956
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
43
Numéro
8
Pages
749-753
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Inflammatory processes may substantially contribute to the cerebral pathology in Alzheimer's disease (AD) and accelerate the disease progression. The macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine which promotes the production of several inflammatory mediators such as TNF-alpha, IL-6 and IFN-gamma, and plays a central regulatory role in the pathogenesis of several inflammatory and autoimmune diseases. There is now first evidence that MIF may be involved in the neuroinflammation in AD. To determine whether MIF production is up-regulated early in the course of AD, we compared the levels of MIF assessed by ELISA in the cerebrospinal fluid (CSF) of 31 patients with AD, 28 patients with amnestic mild cognitive impairment (MCI), and 19 subjects without cognitive deficits. Additionally, we measured the CSF concentrations of the inflammatory mediators TNF-alpha, IL-6 and IFN-gamma, which are thought to be both up-regulated by MIF and involved in the pathophysiology of AD. CSF MIF concentrations were significantly increased in AD (p=0.003) and MCI patients (p<0.001) compared to controls. The levels of TNF-alpha, IL-6 and IFN-gamma did not differ significantly between the groups. There was a correlation only between the concentrations of MIF and of TNF-alpha in the AD group (r=0.407; p=0.023). These results demonstrate increased MIF production in AD and MCI suggesting that MIF may be involved in the occurring neuroinflammatory process at a clinical pre-dementia disease stage.
Mots-clé
Aged, Aged, 80 and over, Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/immunology, Cognition Disorders/cerebrospinal fluid, Cognition Disorders/immunology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interferon-gamma/cerebrospinal fluid, Interleukin-6/cerebrospinal fluid, Macrophage Migration-Inhibitory Factors/cerebrospinal fluid, Macrophage Migration-Inhibitory Factors/immunology, Male, Middle Aged, Severity of Illness Index, Tumor Necrosis Factor-alpha/cerebrospinal fluid, Up-Regulation
Pubmed
Création de la notice
29/10/2012 11:53
Dernière modification de la notice
03/03/2018 19:55
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