BK Polyomavirus-Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study.

Détails

ID Serval
serval:BIB_9BFE3E689546
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
BK Polyomavirus-Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study.
Périodique
American journal of transplantation
Auteur(s)
Leboeuf C., Wilk S., Achermann R., Binet I., Golshayan D., Hadaya K., Hirzel C., Hoffmann M., Huynh-Do U., Koller M.T., Manuel O., Mueller N.J., Mueller T.F., Schaub S., van Delden C., Weissbach F.H., Hirsch H.H.
Collaborateur(s)
Swiss Transplant Cohort Study
Contributeur(s)
Amico P., Aubert J.D., Banz V., Beldi G., Benden C., Berger C., Bochud P.Y., Bucher H., Bühler L., Carell T., Catana E., Chalandon Y., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Fehr T., Ferrari-Lacraz S., Garzoni C., Soccal P.G., Gaudet C., Giostra E., Halter J., Heim D., Hess C., Hillinger S., Hofbauer G., Immer F., Klaghofer R., Laesser B., Lehmann R., Lovis C., Marti H.P., Martin P.Y., Meylan P., Mohacsi P., Morel P., Mueller U., Mueller-McKenna H., Müller A., Müller T., Müllhaupt B., Nadal D., Pascual M., Passweg J., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schnyder A., Seiler C., Stampf S., Steiger J., Stirnimann G., Toso C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
17
Numéro
10
Pages
2591-2600
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Because antivirals are lacking, most programs screen for BKPyV-viremia and, if positive, reduce immunosuppression. To evaluate the relationship of viremia and BKPyV-specific immunity, we examined prospectively cryopreserved plasma and peripheral blood mononuclear cells at the time of transplantation (T0) and at 6 mo (T6) and 12 mo (T12) after transplant from 28 viremic KT patients and 68 nonviremic controls matched for the transplantation period. BKPyV IgG seroprevalence was comparable between cases (89.3%) and controls (91.2%; p = 0.8635), but cases had lower antibody levels (p = 0.022) at T0. Antibody levels increased at T6 and T12 but were not correlated with viremia clearance. BKPyV-specific T cell responses to pools of overlapping 15mers (15mer peptide pool [15mP]) or immunodominant CD8 9mers (9mer peptide pool [9mP]) from the early viral gene region were not different between cases and controls at T0; however, clearance of viremia was associated with stronger 9mP responses at T6 (p = 0.042) and T12 (p = 0.048), whereas 15mP responses were not informative (T6 p = 0.359; T12 p = 0.856). BKPyV-specific T cells could be expanded in vitro from all patients after transplant, permitting identification of 78 immunodominant 9mer epitopes including 50 new ones across different HLA class I. Thus, 9mP-responses may be a novel marker of reconstituting CD8 T cell function that warrants further study as a complement of plasma BKPyV loads for guiding immunosuppression reduction.
Mots-clé
Adult, Aged, BK Virus/isolation & purification, BK Virus/physiology, CD8-Positive T-Lymphocytes/immunology, Case-Control Studies, Cohort Studies, Female, Humans, Kidney Transplantation/adverse effects, Male, Middle Aged, Viremia, T cell biology, antigen presentation/recognition, infection and infectious agents, infectious disease, kidney transplantation/nephrology, translational research/science, viral: BK/JC/polyoma
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/03/2017 17:41
Dernière modification de la notice
08/05/2019 22:39
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