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Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver
Eur J Surg Oncol
1532-2157 (Electronic)0748-7983 (Linking)
Elias, DGoere, DLeroux, GDromain, CLeboulleux, Sde Baere, ThDucreux, MBaudin, EengEngland2009/05/26 09:00Eur J Surg Oncol. 2009 Oct;35(10):1092-7. doi: 10.1016/j.ejso.2009.02.017. Epub 2009 May 21.
AIM: The aim of this study was to report the feasibility and early survival results of liver metastases (LM) resection combining cytoreductive surgery and radiofrequency ablation (RFA) during a one-step procedure, in patients presenting more than 15 bilateral LM from well-differentiated endocrine carcinoma. It is an extensive application of the current guidelines. METHODS: In this retrospective review of a prospectively collected database, we used a combination of hepatectomy to treat large or contiguous LM, and extensively used multiple RFA to treat the remaining LM which were smaller than 2.5 cm. Patients were selected based on a low natural tumor burden slope, and the technical feasibility of treating all the detectable LM. RESULTS: From January 2002 to May 2007, 16 patients with a median of 23 LM per patient (mean number: 25.7 + or -12; range16-89) underwent this procedure. A mean of 15 + or - 9 LM per patient were surgically removed and a mean of 12 + or - 8 (median of 10) LM per patient were RF ablated. No mortality occurred. Morbidity was observed in 11 patients (69%). The 3-year overall survival and disease-free survival rates were similar to those observed in our preliminary series of 47 hepatectomized patients with a median of 7 LM per patient. CONCLUSION: This new one-step combined technique allowed us to apply an "upgraded" therapeutic approach to a selection of patients presenting a median of 23 LM per patient and to improve their prognosis, putting it on par with that obtained by conventional hepatectomy.
Adult, *Catheter Ablation, Combined Modality Therapy, Feasibility Studies, Female, Gastrointestinal Neoplasms/pathology, *Hepatectomy, Humans, Liver Neoplasms/*secondary/*surgery, Male, Middle Aged, Neuroendocrine Tumors/*secondary/*surgery, Pancreatic Neoplasms/pathology, Retrospective Studies, Survival Analysis
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