New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Horikoshi, M.; Yaghootkar, H.; Mook-Kanamori, D.O.; Sovio, U.; Taal, H.R.; Hennig, B.J.; Bradfield, J.P.; St Pourcain, B.; Evans, D.M.; Charoen, P.; Kaakinen, M.; Cousminer, D.L.; Lehtimäki, T.; Kreiner-Møller, E.; Warrington, N.M.; Bustamante, M.; Feenstra, B.; Berry, D.J.; Thiering, E.; Pfab, T.; Barton, S.J.; Shields, B.M.; Kerkhof, M.; van Leeuwen, E.M.; Fulford, A.J.; Kutalik, Z.; Zhao, J.H.; den Hoed, M.; Mahajan, A.; Lindi, V.; Goh, L.K.; Hottenga, J.J.; Wu, Y.; Raitakari, O.T.; Harder, M.N.; Meirhaeghe, A.; Ntalla, I.; Salem, R.M.; Jameson, K.A.; Zhou, K.; Monies, D.M.; Lagou, V.; Kirin, M.; Heikkinen, J.; Adair, L.S.; Alkuraya, F.S.; Al-Odaib, A.; Amouyel, P.; Andersson, E.A.; Bennett, A.J.; Blakemore, A.I.; Buxton, J.L.; Dallongeville, J.; Das, S.; de Geus, E.J.; Estivill, X.; Flexeder, C.; Froguel, P.; Geller, F.; Godfrey, K.M.; Gottrand, F.; Groves, C.J.; Hansen, T.; Hirschhorn, J.N.; Hofman, A.; Hollegaard, M.V.; Hougaard, D.M.; Hyppönen, E.; Inskip, H.M.; Isaacs, A.; Jørgensen, T.; Kanaka-Gantenbein, C.; Kemp, J.P.; Kiess, W.; Kilpeläinen, T.O.; Klopp, N.; Knight, B.A.; Kuzawa, C.W.; McMahon, G.; Newnham, J.P.; Niinikoski, H.; Oostra, B.A.; Pedersen, L.; Postma, D.S.; Ring, S.M.; Rivadeneira, F.; Robertson, N.R.; Sebert, S.; Simell, O.; Slowinski, T.; Tiesler, C.M.; Tönjes, A.; Vaag, A.; Viikari, J.S.; Vink, J.M.; Vissing, N.H.; Wareham, N.J.; Willemsen, G.; Witte, D.R.; Zhang, H.; Zhao, J.; Meta-Analyses of, Glucose-; Wilson, J.F.; Wilson, J.F.; Stumvoll, M.; Prentice, A.M.; Meyer, B.F.; Pearson, E.R.; Boreham, C.A.; Cooper, C.; Gillman, M.W.; Dedoussis, G.V.; Moreno, L.A.; Pedersen, O.; Saarinen, M.; Mohlke, K.L.; Boomsma, D.I.; Saw, S.M.; Lakka, T.A.; Körner, A.; Loos, R.J.; Ong, K.K.; Vollenweider, P.; van Duijn, C.M.; Koppelman, G.H.; Hattersley, A.T.; Holloway, J.W.; Hocher, B.; Heinrich, J.; Power, C.; Melbye, M.; Guxens, M.; Pennell, C.E.; Bønnelykke, K.; Bisgaard, H.; Eriksson, J.G.; Widén, E.; Hakonarson, H.; Uitterlinden, A.G.; Pouta, A.; Lawlor, D.A.; Smith, G.D.; Frayling, T.M.; McCarthy, M.I.; Grant, S.F.; Jaddoe, V.W.; Jarvelin, M.R.; Timpson, N.J.; Prokopenko, I.; Freathy, R.M.

doi:10.1038/ng.2477

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

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Serval ID

serval:BIB_9BEFC7CAA18D

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Journal

Nature Genetics

Author(s)

Horikoshi M., Yaghootkar H., Mook-Kanamori D.O., Sovio U., Taal H.R., Hennig B.J., Bradfield J.P., St Pourcain B., Evans D.M., Charoen P., Kaakinen M., Cousminer D.L., Lehtimäki T., Kreiner-Møller E., Warrington N.M., Bustamante M., Feenstra B., Berry D.J., Thiering E., Pfab T., Barton S.J., Shields B.M., Kerkhof M., van Leeuwen E.M., Fulford A.J., Kutalik Z., Zhao J.H., den Hoed M., Mahajan A., Lindi V., Goh L.K., Hottenga J.J., Wu Y., Raitakari O.T., Harder M.N., Meirhaeghe A., Ntalla I., Salem R.M., Jameson K.A., Zhou K., Monies D.M., Lagou V., Kirin M., Heikkinen J., Adair L.S., Alkuraya F.S., Al-Odaib A., Amouyel P., Andersson E.A., Bennett A.J., Blakemore A.I., Buxton J.L., Dallongeville J., Das S., de Geus E.J., Estivill X., Flexeder C., Froguel P., Geller F., Godfrey K.M., Gottrand F., Groves C.J., Hansen T., Hirschhorn J.N., Hofman A., Hollegaard M.V., Hougaard D.M., Hyppönen E., Inskip H.M., Isaacs A., Jørgensen T., Kanaka-Gantenbein C., Kemp J.P., Kiess W., Kilpeläinen T.O., Klopp N., Knight B.A., Kuzawa C.W., McMahon G., Newnham J.P., Niinikoski H., Oostra B.A., Pedersen L., Postma D.S., Ring S.M., Rivadeneira F., Robertson N.R., Sebert S., Simell O., Slowinski T., Tiesler C.M., Tönjes A., Vaag A., Viikari J.S., Vink J.M., Vissing N.H., Wareham N.J., Willemsen G., Witte D.R., Zhang H., Zhao J., Meta-Analyses of Glucose-, Wilson J.F., Wilson J.F., Stumvoll M., Prentice A.M., Meyer B.F., Pearson E.R., Boreham C.A., Cooper C., Gillman M.W., Dedoussis G.V., Moreno L.A., Pedersen O., Saarinen M., Mohlke K.L., Boomsma D.I., Saw S.M., Lakka T.A., Körner A., Loos R.J., Ong K.K., Vollenweider P., van Duijn C.M., Koppelman G.H., Hattersley A.T., Holloway J.W., Hocher B., Heinrich J., Power C., Melbye M., Guxens M., Pennell C.E., Bønnelykke K., Bisgaard H., Eriksson J.G., Widén E., Hakonarson H., Uitterlinden A.G., Pouta A., Lawlor D.A., Smith G.D., Frayling T.M., McCarthy M.I., Grant S.F., Jaddoe V.W., Jarvelin M.R., Timpson N.J., Prokopenko I., Freathy R.M.

Working group(s)

Insulin-related traits Consortium (MAGIC), Early Growth Genetics (EGG) Consortium

Contributor(s)

Meta-Analyses of Glucose-

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

12/2013

Volume

Number

Pages

76-82

Language

english

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish. PDF type: article

Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

Keywords

Adult, Birth Weight/genetics, Blood Pressure/genetics, Body Height/genetics, Diabetes Mellitus, Type 2/genetics, Female, Fetal Development/genetics, Genetic Linkage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Infant, Newborn, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci

URN

urn:nbn:ch:serval-BIB_9BEFC7CAA18D4

OAI-PMH

oai:serval.unil.ch:BIB_9BEFC7CAA18D

DOI

10.1038/ng.2477

Pubmed

23202124

Create date

10/01/2013 12:56

Last modification date

30/04/2021 7:13

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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Details