Dynamics of case-fatalilty rates of recurrent thromboembolism and major bleeding in patients treated for venous thromboembolism.
Details
Serval ID
serval:BIB_9BC370C12A38
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dynamics of case-fatalilty rates of recurrent thromboembolism and major bleeding in patients treated for venous thromboembolism.
Journal
Thrombosis and Haemostasis
Working group(s)
RIETE investigators
Contributor(s)
Monreal M., Decousus H., Prandoni P., Brenner B., Barba R., Di Micco P., Bertoletti L., Papadakis M., Bosevski M., Bounameaux H., Malý R., Arcelus JI., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Blanco-Molina A., Bosco J., Bueso T., Cañas I., Casado I., Conget F., de Miguel J., del Campo R., Chaves E., Di Yacobo MS. , del Toro J., Falgá C., Fernández-Capitán C., Gabriel F., Gallego P., García-Bragado F., Gómez V., González J., Guil M., Guillem N., Gutiérrez J., Hernández L., Hernández-Huerta D., Jaras MJ., Jiménez D., Jiménez S., Lladó M., Lobo JL., Lecumberri R., López-Jiménez L., Lorenzo A., Macià M., Madridano O., Marchena PJ., Martín M., Martín-Villasclaras JJ., Monreal M., Morales M., Nauffal MD., Nieto JA., Núñez MJ., Ogea JL., Otero R., Pedrajas JM., Riera-Mestre A., Rodríguez-Dávila MA., Román P., Román-Bernal B., Rosa V., Royo C., Ruíz J., Ruiz-Gamietea A., Ruiz-Giménez N., Sahuquillo JC., Sánchez R., Sánchez Muñoz-Torrero JF. , Soler S., Soto MJ., Tiberio G., Tolosa C., Trujillo J., Uresandi F., Valdés M., Valle R., Vela J., Vidal G., Villalta J., Zorrilla V., Bertoletti L., Bura-Riviere A., Debourdeau P., Farge-Bancel D., Lamuraglia M., Mahe I., Quere I., Babalis D., Papadakis M., Brenner B., Barillari G., Ciammaichella M., Di Micco P., Dalla Valle F., Duce R., La Regina M., Maida R., Orlandini F., Pasca S., Piovella C., Poggio R., Prandoni P., Quintavalla R., Rota L., Schenone A., Tiraferri E., Tonello D., Visonà A., Zalunardo B., Bosevski M., Alatri A., Bounameaux H., Calanca L., Mazzolai L., Malý R., Hirmerova J., Salgado E., Wells P.
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Publication state
Published
Issued date
2013
Volume
110
Number
4
Pages
834-843
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. Alatri fait partie de RIETE investigators
Abstract
In patients with venous thromboembolism (VTE), assessment of the risk of fatal recurrent VTE and fatal bleeding during anticoagulation may help to guide intensity and duration of therapy. We aimed to provide estimates of the case-fatality rate (CFR) of recurrent VTE and major bleeding during anticoagulation in a 'real life' population, and to assess these outcomes according to the initial presentation of VTE and its etiology. The study included 41,826 patients with confirmed VTE from the RIETE registry who received different durations of anticoagulation (mean 7.8 ± 0.6 months). During 27,110 patient-years, the CFR was 12.1% (95% CI, 10.2-14.2) for recurrent VTE, and 19.7% (95% CI, 17.4-22.1) for major bleeding. During the first three months of anticoagulant therapy, the CFR of recurrent VTE was 16.1% (95% CI, 13.6-18.9), compared to 2.0% (95% CI, 0-4.2) beyond this period. The CFR of bleeding was 20.2% (95% CI, 17.5-23.1) during the first three months, compared to 18.2% (95% CI, 14.0-23.2) beyond this period. The CFR of recurrent VTE was higher in patients initially presenting with PE (18.5%; 95% CI, 15.3-22.1) than in those with DVT (6.3%; 95% CI, 4.5-8.6), and in patients with provoked VTE (16.3%; 95% CI, 13.6-19.4) than in those with unprovoked VTE (5.5%; 95% CI, 3.5-8.0). In conclusion, the CFR of recurrent VTE decreased over time during anticoagulation, while the CFR of major bleeding remained stable. The CFR of recurrent VTE was higher in patients initially presenting with PE and in those with provoked VTE.
Pubmed
Web of science
Create date
11/02/2014 17:24
Last modification date
28/05/2020 6:26
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