Article: article from journal or magazin.
Letter (letter): Communication to the publisher.
Regulation of inflammatory responses by the commensal microbiota.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
It is well established that dysregulation of the interactions between the immune system and commensal bacteria is one factor that underpins the development and chronicity of a number of inflammatory diseases. Certain phyla of bacteria within the microbiota have been associated with 'health', but the mechanisms by which the presence of these bacteria supports a healthy environment are still being unravelled. Recent evidence indicates that one such mechanism involves the anti-inflammatory properties of fermentation products of fibre, short-chain fatty acids and their signalling through the G-protein coupled receptor GPR43. Recent findings also indicate that, even in health, bacterial communities harbour in the airways, indicating that direct exposure to bacterial products at this site may provide a further explanation for how commensal bacteria can regulate chronic airway inflammation.
Bacteria/genetics, Bacteria/growth & development, Gastrointestinal Tract/microbiology, Humans, Immunity, Innate, Inflammation/immunology, Inflammation/metabolism, Metagenome, Symbiosis/immunology
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