Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_9B972D023A05
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Périodique
Cell reports
Auteur(s)
Bartolini G., Sánchez-Alcañiz J. A, Osório C., Valiente M., García-Frigola C, Marín O.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
18
Numéro
5
Pages
1157-1170
Langue
anglais
Résumé
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/04/2017 10:02
Dernière modification de la notice
20/08/2019 16:02
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