Study of large inbred Friedreich ataxia families reveals a recombination between D9S15 and the disease locus

Details

Serval ID
serval:BIB_9B64528D8B23
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Study of large inbred Friedreich ataxia families reveals a recombination between D9S15 and the disease locus
Journal
American Journal of Human Genetics
Author(s)
Belal  S., Panayides  K., Sirugo  G., Ben Hamida  C., Ioannou  P., Hentati  F., Beckmann  J., Koenig  M., Mandel  J. L., Ben Hamida  M., Middleton L.T.
ISSN
0002-9297 (Print)
Publication state
Published
Issued date
12/1992
Volume
51
Number
6
Pages
1372-6
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
Friedreich ataxia is a neurodegenerative disorder with autosomal recessive inheritance. Precise linkage mapping of the Friedreich ataxia locus (FRDA) in 9q13-q21 should lead to the isolation of the defective gene by positional cloning. The two closest DNA markers, D9S5 and D9S15, show very tight linkage to FRDA, making difficult the ordering of the three loci. We present a linkage study of three large Friedreich ataxia families of Tunisian origin, with several multiallelic markers around D9S5 and D9S15. Haplotype data were used to investigate genetic homogeneity of the disease in these geographically related families. A meiotic recombination was found in a nonaffected individual, which excludes a 150-kb segment, including D9S15, as a possible location for the Friedreich ataxia gene and which should orient the search in the D9S5 region.
Keywords
Adolescent Adult Chromosome Mapping *Chromosomes, Human, Pair 9 Consanguinity Female Friedreich Ataxia/*genetics Haplotypes Humans Linkage (Genetics) Lod Score Male Pedigree *Recombination, Genetic
Pubmed
Web of science
Create date
25/01/2008 16:18
Last modification date
20/08/2019 15:02
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