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Host genetic determinants of spontaneous hepatitis C clearance
Acute infection with the hepatitis C virus (HCV) induces a wide range of innate and adaptive immune responses. A total of 20-50% of acutely HCV-infected individuals permanently control the virus, referred to as 'spontaneous hepatitis C clearance', while the infection progresses to chronic hepatitis C in the majority of cases. Numerous studies have examined host genetic determinants of hepatitis C infection outcome and revealed the influence of genetic polymorphisms of human leukocyte antigens, killer immunoglobulin-like receptors, chemokines, interleukins and interferon-stimulated genes on spontaneous hepatitis C clearance. However, most genetic associations were not confirmed in independent cohorts, revealed opposing results in diverse populations or were limited by varying definitions of hepatitis C outcomes or small sample size. Coordinated efforts are needed in the search for key genetic determinants of spontaneous hepatitis C clearance that include well-conducted candidate genetic and genome-wide association studies, direct sequencing and follow-up functional studies.
association studies, genetics, hepatitis C, spontaneous hepatitis C clearance, Necrosis-Factor-Alpha, Class-Ii Alleles, Single Nucleotide Polymorphisms, Hiv-Infected Patients, Immunoglobulin-Like Receptors, Spontaneous Viral Clearance, Treatment-Induced Recovery, Cellular Immune-Responses, Natural-Killer-Cells, Antigen Class-II
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