Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Botulinumtoxin bei nichtneurogenen Blasenfunktionsstörungen [Botulinum toxin in nonneurogenic bladder dysfunction].
Urologe. Ausgabe A
Publication types: English Abstract ; Journal Article ; ReviewPublication Status: ppublish
Nonneurogenic overactive bladder with or without detrusor overactivity and/or incontinence is a bothersome symptom for many people. Until a few years ago, it could be treated only with anticholinergic drugs or invasive surgery. Intradetrusor injection with botulinum toxin type A is a minimally invasive alternative therapy option for patients who do not respond to or tolerate anticholinergic treatment. This literature overview summarises the relevant articles on this topic over the last 6 years and provides information on the efficacy, adverse events, currently used dosages, and injection techniques. Overall, a favourable initial efficacy has been observed starting around day 4 after injection and can last up to approximately 31 weeks. Depending on the dose, however, elevated postvoid residual volumes should be anticipated and might require clean intermittent self-catheterisation. The use of botulinum toxin in the urinary bladder is still considered off-label.
Botulinum Toxins/administration & dosage, Botulinum Toxins/adverse effects, Dose-Response Relationship, Drug, Humans, Urinary Bladder, Neurogenic, Urinary Bladder, Overactive/drug therapy, Urinary Bladder, Overactive/prevention & control
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