Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes.

Détails

ID Serval
serval:BIB_9AE098AB1330
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes.
Périodique
Diabetes Care
Auteur(s)
D'Addio F., Maffi P., Vezzulli P., Vergani A., Mello A., Bassi R., Nano R., Falautano M., Coppi E., Finzi G., D'Angelo A., Fermo I., Pellegatta F., La Rosa S., Magnani G., Piemonti L., Falini A., Folli F., Secchi A., Fiorina P.
ISSN
1935-5548 (Electronic)
ISSN-L
0149-5992
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
37
Numéro
1
Pages
267-276
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
OBJECTIVE Islets after kidney transplantation have been shown to positively affect the quality of life of individuals with type 1 diabetes (T1D) by reducing the burden of diabetes complications, but fewer data are available for islet transplantation alone (ITA). The aim of this study was to assess whether ITA has a positive impact on hemostatic and cerebral abnormalities in individuals with T1D. RESEARCH DESIGN AND METHODS Prothrombotic factors, platelet function/ultrastructure, and cerebral morphology, metabolism, and function have been investigated over a 15-month follow-up period using ELISA/electron microscopy and magnetic resonance imaging, nuclear magnetic resonance spectroscopy, and neuropsychological evaluation (Profile of Mood States test and paced auditory serial addition test) in 22 individuals with T1D who underwent ITA (n = 12) or remained on the waiting list (n = 10). Patients were homogeneous with regard to metabolic criteria, hemostatic parameters, and cerebral morphology/metabolism/function at the time of enrollment on the waiting list. RESULTS At the 15-month follow-up, the group undergoing ITA, but not individuals with T1D who remained on the waiting list, showed 1) improved glucose metabolism; 2) near-normal platelet activation and prothrombotic factor levels; 3) near-normal cerebral metabolism and function; and 4) a near-normal neuropsychological test. CONCLUSIONS ITA, despite immunosuppressive therapy, is associated with a near-normalization of hemostatic and cerebral abnormalities.
Mots-clé
Adult, Blood Glucose/metabolism, Blood Platelets/pathology, Blood Platelets/physiology, Brain/metabolism, Brain/pathology, Diabetes Mellitus, Type 1/pathology, Diabetes Mellitus, Type 1/physiopathology, Female, Hemostasis, Humans, Immunosuppressive Agents/therapeutic use, Islets of Langerhans Transplantation, Male, Pilot Projects, Quality of Life, Retrospective Studies
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/09/2016 12:51
Dernière modification de la notice
20/08/2019 15:01
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