Functional role of RXRs and PPARgamma in mature adipocytes.

Details

Serval ID
serval:BIB_9AAC145A821E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional role of RXRs and PPARgamma in mature adipocytes.
Journal
Prostaglandins, Leukotrienes, and Essential Fatty Acids
Author(s)
Metzger D., Imai T., Jiang M., Takukawa R., Desvergne B., Wahli W., Chambon P.
ISSN
0952-3278[print], 0952-3278[linking]
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
73
Number
1
Pages
51-58
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The peroxisome proliferator-activated receptor gamma (PPARgamma) is abundantly expressed in adipocytes, and plays an important role in adipocyte differentiation and fat accretion. It is a heterodimeric partner of the retinoid X receptors alpha, beta and gamma, which are also expressed in the adipose tissue. As lethality of PPARgamma(-/-) and RXRalpha(-/-) mouse fetuses precluded the analysis of PPARgamma and RXRalpha functions in mature adipocytes, we generated RXRalpha(ad-/-) and PPARgamma(ad-/-) mice, in which RXRalpha and PPARgamma are selectively ablated in adult adipocytes, respectively. Even though the adiposity of RXRalpha(ad-/-) mice is similar to that of control mice when fed a regular diet, they are resistant to chemically and dietary-induced obesity. However, mature adipocytes lacking either both RXRalpha and RXRgamma or PPARgamma die, and are replaced by newly formed adipocytes. Thus, in adipocytes, RXRalpha is essential for lipogenesis, but RXRgamma can functionally replace RXRalpha for the adipocyte vital functions exerted by PPARgamma/RXR heterodimers.
Keywords
Adipocytes/drug effects, Adipocytes/pathology, Animals, Cell Death/genetics, Cell Differentiation/genetics, Dimerization, Genetic Predisposition to Disease, Mice, Mice, Transgenic, Obesity/genetics, Obesity/pathology, PPAR gamma/physiology, Retinoid X Receptor alpha/genetics, Retinoid X Receptor alpha/metabolism, Retinoid X Receptor gamma/genetics, Retinoid X Receptor gamma/metabolism, Sodium Glutamate/adverse effects, Tamoxifen/pharmacology
Pubmed
Web of science
Create date
24/01/2008 15:27
Last modification date
20/08/2019 15:01
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