Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Cytomegalovirus (CMV)-specific cellular immune responses.
Publication types: Journal Article ; Review - Publication Status: ppublish
A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of the current strategies to identify CMV-specific T cells are centered on the assessment of the functions of memory T cells including their ability to mediate effector function, to proliferate or to secrete cytokines following antigen-specific stimulation. The investigation of these functions has allowed the characterization of the CMV-specific T-cell responses that are present during different phases of the infection. Furthermore, it has also been shown that the combination of virus-specific CD4 and CD8 T-cell responses are critical components of the immune response in the control of virus replication.
CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cytomegalovirus, Cytomegalovirus Infections, Flow Cytometry, HIV-1, Histocompatibility Antigens Class I, Humans, Immunity, Cellular, Immunologic Surveillance, Interferon-gamma, Monitoring, Immunologic, Phosphoproteins, Receptors, CCR7, Receptors, Chemokine, Transplantation, Viral Matrix Proteins
Web of science
Last modification date