Nonvascularized human skin chronic allograft rejection.

Détails

Ressource 1Demande d'une copie Sous embargo jusqu'au 07/08/2020.
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_99FA1291AC19
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Nonvascularized human skin chronic allograft rejection.
Périodique
American journal of transplantation
Auteur(s)
Rotman S., Koch N., Wiesner L., Aubert V., Rosales I.A., Colvin R.B., Raffoul W., Pascual M.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Statut éditorial
In Press
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Case Reports
Publication Status: aheadofprint
Résumé
A 65-year-old man had extensive burns of the lower legs in 1991, at the age of 40 years. He was treated by nonvascularized and de-epithelialized, allogeneic split-thickness skin allograft and cyclosporine monotherapy for 2 months. Ulcers developed between 10 and 25 years after transplantation and a surgical debridement on the lower extremities was required. Analyses of the removed tissue allografts showed chronic antibody-mediated and cellular rejection with extensive and dense fibrosis, and diffuse capillary C4d deposits. An anti-DRB1*08:01, donor-specific antibody was present. A unique clinical condition with late immunopathological features of human skin chronic allograft rejection is reported.
Mots-clé
accommodation, alloantibody, clinical research/practice, ethics and public policy, organ transplantation in general, pathology/histopathology, rejection: antibody-mediated (ABMR), surgical technique, tolerance, vascularized composite and reconstructive transplantation
Pubmed
Web of science
Création de la notice
26/07/2019 13:28
Dernière modification de la notice
16/10/2019 5:13
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