Dynamic computed tomography with low- and high-molecular-mass contrast agents to assess microvascular permeability modifications in a model of liver fibrosis.

Détails

ID Serval
serval:BIB_99D4E782DAA9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dynamic computed tomography with low- and high-molecular-mass contrast agents to assess microvascular permeability modifications in a model of liver fibrosis.
Périodique
Clinical Science (london, England : 1979)
Auteur(s)
Materne R., Annet L., Dechambre S., Sempoux C., Smith A.M., Corot C., Horsmans Y., Van Beers B.E.
ISSN
0143-5221 (Print)
ISSN-L
0143-5221
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
103
Numéro
2
Pages
213-216
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Interstitial collagen formation and transformation of the fenestrated hepatic sinusoids into continuous capillaries are major ultrastructural changes that occur in liver cirrhosis and fibrosis. These modifications lead to progressive restriction of blood-liver exchanges. The purpose of our study was to evaluate the permeability changes in a model of hepatic fibrosis by using dynamic computed tomography (CT) enhanced with contrast agents of different molecular masses. Dynamic single-section CT of the liver was performed after intravenous bolus administration of a low-molecular-mass contrast agent (iobitridol) and an experimental high-molecular-mass agent (P840) in normal control rabbits and in rabbits with hepatic fibrosis. Hepatic, aortic and portal venous time-density curves were fitted with a dual-input one-compartmental model to calculate the hepatic mean transit time and distribution volume of the contrast agents. In the rabbits with liver fibrosis, the mean transit time of the high-molecular-mass agent was shorter than that of the low-molecular-mass agent (10.0+/-1.8 s and 12.0+/-1.2 s respectively; P<0.05). The distribution volume accessible to the high-molecular-mass agent was also smaller (22.2+/-4.8% compared with 32.0+/-6.7%; P<0.01). In the normal rabbits, the mean transit times of the high- and low-molecular-mass agents did not differ significantly, and nor did their distribution volumes. Our results demonstrate decreased sinusoidal permeability for the high-molecular-mass agent P840 in a model of hepatic fibrosis. Non-invasive assessment of permeability changes in liver fibrosis can be performed with dynamic CT and contrast agents of different molecular masses.
Mots-clé
Animals, Capillary Permeability, Contrast Media/pharmacokinetics, Iohexol/analogs & derivatives, Iohexol/pharmacokinetics, Liver/physiopathology, Liver/radiography, Liver Cirrhosis/physiopathology, Liver Cirrhosis/radiography, Male, Molecular Weight, Rabbits, Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
20/10/2016 17:29
Dernière modification de la notice
03/03/2018 19:51
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