Hepatitis E virus as a cause of acute hepatitis acquired in Switzerland.

Détails

ID Serval
serval:BIB_989825B85C8C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hepatitis E virus as a cause of acute hepatitis acquired in Switzerland.
Périodique
Liver international
Auteur(s)
Fraga M., Doerig C., Moulin H., Bihl F., Brunner F., Müllhaupt B., Ripellino P., Semela D., Stickel F., Terziroli Beretta-Piccoli B., Aubert V., Telenti A., Greub G., Sahli R., Moradpour D.
ISSN
1478-3231 (Electronic)
ISSN-L
1478-3223
Statut éditorial
Publié
Date de publication
04/2018
Peer-reviewed
Oui
Volume
38
Numéro
4
Pages
619-626
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Autochthonous hepatitis E is increasingly recognized as zoonotic infection in western countries. Serological assays have varying sensitivity and specificity.
We implemented molecular testing to identify and characterize acute hepatitis E acquired in Switzerland.
Ninety-three cases of mostly symptomatic acute hepatitis E acquired in Switzerland were documented by PCR between November 2011 and December 2016. Median HEV RNA was 7.5 x 10 <sup>4</sup> IU/mL (range, 5.3 to 4.7 x 10 <sup>7</sup> IU/mL). HEV genotyping was successful in 78 patients, revealing genotype 3 in 75 and genotype 4 in three patients. Phylogenetic analyses revealed a few limited geographical and temporal clusters. Of the 91 patients with available anti-HEV IgM serology, four were negative; three of these were also IgG-negative, likely as a result of immunosuppression, and one was IgG-positive, a constellation compatible with HEV reinfection. Median age of the patients was 58 years (range, 20-80 years); 71 (76.3%) were men and 49 of these (69.0%) were ≥ 50 years old. The clinical course was particularly severe in patients with underlying chronic liver disease, with fatal outcome in two patients. Six patients (6.5%) presented with neuralgic amyotrophy.
Nucleic acid-based diagnosis reveals HEV as a relevant cause of acute hepatitis in Switzerland. Middle-aged and elderly men constitute the majority of symptomatic patients. Testing for HEV should be included early in the diagnostic workup of acute hepatitis and of neuralgic amyotrophy, a typical extrahepatic manifestation of HEV genotype 3 infection.
Mots-clé
Acute Disease, Adult, Age Distribution, Aged, Aged, 80 and over, Brachial Plexus Neuritis/complications, Female, Genotype, Hepatitis Antibodies/blood, Hepatitis E/diagnosis, Hepatitis E/epidemiology, Hepatitis E virus/genetics, Hepatitis E virus/isolation & purification, Humans, Immunoglobulin G/blood, Immunoglobulin M/blood, Male, Middle Aged, Phylogeny, RNA, Viral/blood, Sex Distribution, Switzerland/epidemiology, Young Adult, acute-on-chronic liver failure, genotyping, hepatitis E virus, neuralgic amyotrophy, nucleic acid-based testing, serology
Pubmed
Web of science
Création de la notice
25/08/2017 9:16
Dernière modification de la notice
20/08/2019 15:00
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