High leptin levels are associated with migraine with aura.

Détails

Ressource 1Télécharger: BIB_9874D43FB7CB.P001.pdf (586.54 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_9874D43FB7CB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
High leptin levels are associated with migraine with aura.
Périodique
Cephalalgia
Auteur(s)
Pisanu C., Preisig M., Castelao E., Glaus J., Cunningham J.L., Del Zompo M., Merikangas K.R., Schiöth H.B., Mwinyi J.
ISSN
1468-2982 (Electronic)
ISSN-L
0333-1024
Statut éditorial
Publié
Date de publication
04/2017
Peer-reviewed
Oui
Volume
37
Numéro
5
Pages
435-441
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Background Migraine is a prevalent disorder characterised by recurrent headache attacks preceded or accompanied by aura in a subgroup of patients. Migraine often occurs together with major depressive disorder (MDD). Alterations of adipokine levels have been reported both in migraine and in MDD. In this cross-sectional study, we aimed to assess the associations between serum leptin and adiponectin levels and migraine or migraine subtypes. Analyses were adjusted for a lifetime history of MDD in order to investigate the association between adipokines and migraine under consideration of depression status. Methods We included 3025 participants from the CoLaus/PsyCoLaus study. The impact of leptin and adiponectin levels on a diagnosis of migraine was analysed by binary regression analyses, adjusting for variables known to influence adipokine levels. Subgroup analyses were conducted based on the presence of aura. Results Crude leptin levels were significantly higher in subjects with migraine than controls (Mann-Whitney U = 515,102, p = 6 × 10-7). When performing adjusted analyses, leptin levels were found to be significantly higher in subjects with migraine (odds ratio = 1.22, p = 0.024) and migraine with aura (odds ratio = 1.34, p = 0.004). Conclusion High leptin levels might play a role in the pathogenesis of migraine and migraine with aura.

Mots-clé
Adult, Aged, Biomarkers/blood, Cross-Sectional Studies, Female, Humans, Leptin/blood, Male, Middle Aged, Migraine with Aura/blood, Migraine with Aura/diagnosis, Migraine with Aura/epidemiology, Random Allocation, Switzerland/epidemiology, Migraine, adiponectin, aura, leptin, major depressive disorder
Pubmed
Web of science
Création de la notice
13/06/2016 13:36
Dernière modification de la notice
20/08/2019 16:00
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