Local Renal Circadian Clocks Control Fluid-Electrolyte Homeostasis and BP.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_98248DEAD541
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Local Renal Circadian Clocks Control Fluid-Electrolyte Homeostasis and BP.
Périodique
Journal of the American Society of Nephrology
Auteur(s)
Tokonami N., Mordasini D., Pradervand S., Centeno G., Jouffe C., Maillard M., Bonny O., Gachon F., Gomez R.A., Sequeira-Lopez M.L., Firsov D.
ISSN
1533-3450 (Electronic)
ISSN-L
1046-6673
Statut éditorial
Publié
Date de publication
2014
Volume
25
Numéro
7
Pages
1430-1439
Langue
anglais
Résumé
The circadian timing system is critically involved in the maintenance of fluid and electrolyte balance and BP control. However, the role of peripheral circadian clocks in these homeostatic mechanisms remains unknown. We addressed this question in a mouse model carrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre recombinase under the endogenous Renin promoter (Bmal1(lox/lox)/Ren1(d)Cre mice). Analysis of Bmal1(lox/lox)/Ren1(d)Cre mice showed that the floxed Bmal1 allele was excised in the kidney. In the kidney, BMAL1 protein expression was absent in the renin-secreting granular cells of the juxtaglomerular apparatus and the collecting duct. A partial reduction of BMAL1 expression was observed in the medullary thick ascending limb. Functional analyses showed that Bmal1(lox/lox)/Ren1(d)Cre mice exhibited multiple abnormalities, including increased urine volume, changes in the circadian rhythm of urinary sodium excretion, increased GFR, and significantly reduced plasma aldosterone levels. These changes were accompanied by a reduction in BP. These results show that local renal circadian clocks control body fluid and BP homeostasis.
Pubmed
Web of science
Création de la notice
05/08/2014 17:42
Dernière modification de la notice
20/08/2019 14:59
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