Glucose transporters in the 21st Century.

Détails

ID Serval
serval:BIB_982480052E61
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Glucose transporters in the 21st Century.
Périodique
American Journal of Physiology. Endocrinology and Metabolism
Auteur(s)
Thorens B., Mueckler M.M.
ISSN
1522-1555[electronic], 0193-1849[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
298
Pages
141-5
Langue
anglais
Résumé
The ability to take up and metabolize glucose at the cellular level is a property shared by the vast majority of existing organisms. Most mammalian cells import glucose by a process of facilitative diffusion mediated by members of the Glut (SLC2A) family of membrane transport proteins. Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. The primary physiological substrates for at least half of the 14 Glut proteins are either uncertain or unknown. The well-established glucose transporter isoforms, Gluts 1-4, are known to have distinct regulatory and/or kinetic properties that reflect their specific roles in cellular and whole body glucose homeostasis. Separate review articles on many of the Glut proteins have recently appeared in this journal. Here, we provide a very brief summary of the known properties of the 14 Glut proteins and suggest some avenues of future investigation in this area.
Mots-clé
glucose transporter proteins, myoinositol transporters, urate transporters
Pubmed
Web of science
Création de la notice
01/03/2010 15:43
Dernière modification de la notice
20/08/2019 14:59
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