Effect of added dead space on sleep disordered breathing at high altitude.

Détails

ID Serval
serval:BIB_982119C059D5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of added dead space on sleep disordered breathing at high altitude.
Périodique
Sleep Medicine
Auteur(s)
Lovis A., De Riedmatten M., Greiner D., Lecciso G., Andries D., Scherrer U., Wellman A., Sartori C., Heinzer R.
ISSN
1878-5506 (Electronic)
ISSN-L
1389-9457
Statut éditorial
Publié
Date de publication
2012
Volume
13
Numéro
6
Pages
663-667
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
OBJECTIVE: Sleep disordered breathing with central apnea or hypopnea frequently occurs at high altitude and is thought to be caused by a decrease in blood CO(2) level. The aim of this study was to assess the effects of added respiratory dead space on sleep disordered breathing.¦METHODS: Full polysomnographies were performed on 12 unacclimatized swiss mountaineers (11 males, 1 female, mean age 39±12 y.o.) in Leh, Ladakh (3500m). In random order, half of the night was spent with a 500ml increase in dead space through a custom designed full face mask and the other half without it.¦RESULTS: Baseline data revealed two clearly distinct groups: one with severe sleep disordered breathing (n=5, AHI>30) and the other with moderate to no disordered breathing (n=7, AHI<30). DS markedly improved breathing in the first group (baseline vs DS): apnea hypopnea index (AHI) 70.3±25.8 vs 29.4±6.9 (p=0.013), oxygen desaturation index (ODI): 72.9±24.1/h vs 42.5±14.4 (p=0.031), whereas it had no significant effect in the second group or in the total population. Respiratory events were almost exclusively central apnea or hypopnea. Microarousal index, sleep efficiency, and sleep architecture remained unchanged with DS. A minor increase in mean PtcCO(2) (n=3) was observed with DS.¦CONCLUSION: A 500ml increase in dead space through a fitted mask may improve nocturnal breathing in mountaineers with severe altitude-induced sleep disordered breathing.
Pubmed
Web of science
Création de la notice
02/08/2012 19:09
Dernière modification de la notice
20/08/2019 15:59
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