Article: article from journal or magazin.
Reduced V1 vasopressin binding in the rat nucleus solitarii after nodose ganglionectomy.
Clinical and Experimental Pharmacology and Physiology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
1. Anaesthetized male Sprague-Dawley rats underwent unilateral nodose ganglionectomy or sham operation. 2. One week later hindbrain V1 vasopressin binding site density was assessed by in vitro autoradiography with the selective V1 antagonist radioligand [125I] [d(CH2)5, Sar7]AVP. 3. Specific binding was observed in the nodose ganglion, nucleus tractus solitarius (NTS), area postrema, and inferior olive. Only binding in the medial subnucleus of the NTS was reduced by ipsilateral nodose ganglionectomy. 4. These findings are consistent with V1 vasopressin receptors occurring presynaptically on vagal primary viscerosensory afferent fibres. 5. Such receptors may be involved in the effect of AVP on blood pressure and/or the baroreflex.
Animals, Ganglionectomy, Male, Medulla Oblongata/metabolism, Nodose Ganglion/physiology, Rats, Rats, Inbred Strains, Receptors, Angiotensin/metabolism, Receptors, Vasopressin, Rhombencephalon/metabolism, Vagus Nerve/physiology, Vasopressins/metabolism
Web of science
Last modification date