Transfer insensitive labeling technique (TILT): application to multislice functional perfusion imaging.

Details

Serval ID
serval:BIB_97B28B62CD4A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transfer insensitive labeling technique (TILT): application to multislice functional perfusion imaging.
Journal
Journal of Magnetic Resonance Imaging
Author(s)
Golay X., Stuber M., Pruessmann K.P., Meier D., Boesiger P.
ISSN
1053-1807[print], 1053-1807[linking]
Publication state
Published
Issued date
1999
Volume
9
Number
3
Pages
454-461
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Cerebral blood flow can be studied in a multislice mode with a recently proposed perfusion sequence using inversion of water spins as an endogenous tracer without magnetization transfer artifacts. The magnetization transfer insensitive labeling technique (TILT) has been used for mapping blood flow changes at a microvascular level under motor activation in a multislice mode. In TILT, perfusion mapping is achieved by subtraction of a perfusion-sensitized image from a control image. Perfusion weighting is accomplished by proximal blood labeling using two 90 degrees radiofrequency excitation pulses. For control preparation the labeling pulses are modified such that they have no net effect on blood water magnetization. The percentage of blood flow change, as well as its spatial extent, has been studied in single and multislice modes with varying delays between labeling and imaging. The average perfusion signal change due to activation was 36.9 +/- 9.1% in the single-slice experiments and 38.1 +/- 7.9% in the multislice experiments. The volume of activated brain areas amounted to 1.51 +/- 0.95 cm3 in the contralateral primary motor (M1) area, 0.90 +/- 0.72 cc in the ipsilateral M1 area, 1.27 +/- 0.39 cm3 in the contralateral and 1.42 +/- 0.75 cm3 in the ipsilateral premotor areas, and 0.71 +/- 0.19 cm3 in the supplementary motor area.
Keywords
Artifacts, Brain/anatomy & histology, Brain/blood supply, Brain Mapping/methods, Cerebrovascular Circulation, Humans, Image Enhancement/methods, Magnetic Resonance Imaging/methods, Reference Values, Sensitivity and Specificity, Spin Labels
Pubmed
Web of science
Create date
02/03/2010 16:04
Last modification date
20/08/2019 14:59
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