Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment.

Details

Serval ID
serval:BIB_979348E57031
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment.
Journal
Schizophrenia Research
Author(s)
Rivero G., Gabilondo A.M., García-Sevilla J.A., La Harpe R., Morentín B., Meana J.J.
ISSN
1573-2509 (Electronic)
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
161
Number
2-3
Pages
446-451
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
14-3-3 is a family of conserved regulatory proteins that bind to a multitude of functionally diverse signalling proteins. Various genetic studies and gene expression and proteomic analyses have involved 14-3-3 proteins in schizophrenia (SZ). On the other hand, studies about the status of these proteins in major depressive disorder (MD) are still missing. Immunoreactivity values of cytosolic 14-3-3β and 14-3-3ζ proteins were evaluated by Western blot in prefrontal cortex (PFC) of subjects with schizophrenia (SZ; n=22), subjects with major depressive disorder (MD; n=21) and age-, gender- and postmortem delay-matched control subjects (n=52). The modulation of 14-3-3β and 14-3-3ζ proteins by psychotropic medication was also assessed. The analysis of both proteins in SZ subjects with respect to matched control subjects showed increased 14-3-3β (Δ=33±10%, p<0.05) and 14-3-3ζ (Δ=29±6%, p<0.05) immunoreactivity in antipsychotic-free but not in antipsychotic-treated SZ subjects. Immunoreactivity values of 14-3-3β and 14-3-3ζ were not altered in MD subjects. These results show the specific up-regulation of 14-3-3β and 14-3-3ζ proteins in PFC of SZ subjects and suggest a possible down-regulation of both proteins by antipsychotic treatment.
Pubmed
Web of science
Create date
05/01/2015 9:11
Last modification date
20/08/2019 14:59
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