Do diurnal cortisol levels mediate the association between sleep disturbances and cognitive impairment?

Détails

ID Serval
serval:BIB_9782E4869425
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Do diurnal cortisol levels mediate the association between sleep disturbances and cognitive impairment?
Périodique
Neurobiology of aging
Auteur(s)
Haba-Rubio J., Ouanes S., Franc Y., Marques-Vidal P., Waeber G., Vollenweider P., von Gunten A., Preisig M., Kuehner C., Castelao E., Heinzer R., Popp J.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
69
Pages
65-67
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Previous research found an association between sleep disturbances and cognitive deficits on the one hand, and between increased cortisol levels and poor cognitive performance on the other hand. We hypothesized that cortisol may, at least partially, mediate the link between sleep disturbances and cognitive impairment (CI). We analyzed data from 440 nondemented subjects aged ≥65 years (72.4 ± 4.5 years old, 55.7% women) participating at the population-based CoLaus/PsyCoLaus study, who underwent cognitive evaluation, complete polysomnography and cortisol measures during the day. Subjects with CI (N = 207, 47.05% of the sample) had lower sleep efficiency, less deep sleep (stage N3) and rapid eye movement sleep, and higher apnea/hypopnea index and oxygen desaturation index. After adjustment for possible confounders, oxygen desaturation index (≥4% and ≥6% per hour of sleep) were significantly associated with impaired cognitive performance. The results of Sobel's test for mediation using the regressions between the sleep-related variables and cortisol values, and between the cortisol and the Clinical Dementia Rating score were not significant (all p > 0.05). Our data suggest that sleep-disordered breathing is associated with CI, but that this association is not mediated by increased diurnal cortisol levels.
Mots-clé
Aged, Circadian Rhythm, Cognitive Dysfunction/complications, Cognitive Dysfunction/metabolism, Female, Humans, Hydrocortisone/metabolism, Male, Neuropsychological Tests, Saliva/metabolism, Sleep Wake Disorders/complications, Sleep Wake Disorders/metabolism, Apnea, Cognition, Cortisol, Sleep
Pubmed
Web of science
Création de la notice
11/06/2018 8:23
Dernière modification de la notice
20/08/2019 14:59
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