Evidence for chronic low-grade systemic inflammation in individuals with agoraphobia from a population-based prospective study.

Détails

Ressource 1Télécharger: BIB_973309AC378A.P001.pdf (242.83 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_973309AC378A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evidence for chronic low-grade systemic inflammation in individuals with agoraphobia from a population-based prospective study.
Périodique
Plos One
Auteur(s)
Wagner E.Y., Wagner J.T., Glaus J., Vandeleur C.L., Castelao E., Strippoli M.P., Vollenweider P., Preisig M., von Känel R.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
10
Numéro
4
Pages
e0123757
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
BACKGROUND: Anxiety disorders have been linked to an increased risk of incident coronary heart disease in which inflammation plays a key pathogenic role. To date, no studies have looked at the association between proinflammatory markers and agoraphobia.
METHODS: In a random Swiss population sample of 2890 persons (35-67 years, 53% women), we diagnosed a total of 124 individuals (4.3%) with agoraphobia using a validated semi-structured psychiatric interview. We also assessed socioeconomic status, traditional cardiovascular risk factors (i.e., body mass index, hypertension, blood glucose levels, total cholesterol/high-density lipoprotein-cholesterol ratio), and health behaviors (i.e., smoking, alcohol consumption, and physical activity), and other major psychiatric diseases (other anxiety disorders, major depressive disorder, drug dependence) which were treated as covariates in linear regression models. Circulating levels of inflammatory markers, statistically controlled for the baseline demographic and health-related measures, were determined at a mean follow-up of 5.5 ± 0.4 years (range 4.7 - 8.5).
RESULTS: Individuals with agoraphobia had significantly higher follow-up levels of C-reactive protein (p = 0.007) and tumor-necrosis-factor-α (p = 0.042) as well as lower levels of the cardioprotective marker adiponectin (p = 0.032) than their non-agoraphobic counterparts. Follow-up levels of interleukin (IL)-1β and IL-6 did not significantly differ between the two groups.
CONCLUSIONS: Our results suggest an increase in chronic low-grade inflammation in agoraphobia over time. Such a mechanism might link agoraphobia with an increased risk of atherosclerosis and coronary heart disease, and needs to be tested in longitudinal studies.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/04/2015 16:30
Dernière modification de la notice
27/09/2019 8:59
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