Prediction of early mortality in patients with cancer-associated thrombosis in the RIETE Database.
Details
Serval ID
serval:BIB_9723814C34FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prediction of early mortality in patients with cancer-associated thrombosis in the RIETE Database.
Journal
International angiology
Working group(s)
RIETE Investigators
Contributor(s)
Adarraga M.D., Aibar M.Á., Aibar J., Amado C., Aranda C., Arcelus J.I., Ballaz A., Barba R., Barillari G., Barrón M., Barrón-Andrés B., Bascuñana J., Benzidia I., Bertoletti L., Blanco-Molina Á., Bilora F., Bortoluzzi C., Bosevski M., Bounameaux H., Braester A., Brandolin B., Brenner B., Bucherini E., Bui H.M., Bura-Riviere A., Camón A.M., Caprini J., Carrasco C., Castro J., Cesta A., Ciammaichella M., Cruz J.A., de Ancos C., Del Toro J., Demelo P., Dentali F., Del Carmen Díaz-Pedroche M., Díaz-Peromingo J.A., Di Micco P., Di Pangrazio M., Ellis M., Encabo M., Falgá C., Falvo N., Farfán A.I., Farge-Bancel D., Fernández-Capitán C., Fidalgo M.Á., Font C., Font L., Fresa M., Furest I., García M.A., García-Bragado F., García-Morillo M., García-Raso A., Gavín O., Gil-Díaz A., Gómez V., Gómez-Cuervo C., González-Martínez J., Grandone E., Grau E., Guijarro R., Gutiérrez J., Gutiérrez P., Hernández-Blasco L., Hij A., Hirmerova J., Imbalzano E., Jara-Palomares L., Jaras M.J., Jiménez D., Jou I., Dolores Joya M., Krstevski G., Lessiani G., Lima J., Llamas P., Lobo J.L., López-Jiménez L., López-Miguel P., López-Nuñez J.J., López-Reyes R., Bosco López-Sáez J., Lorente M.A., Lorenzo A., Loring M., Lumbierres M., Mahé I., Maida R., Malý R., Manrique-Abos I., Javier Marchena P., Martín-Fernández M., Martín-Guerra J.M., Martín-Romero M., Mastroiacovo D., Mazzolai L., Mellado M., Merah A., Monreal M., Del Valle Morales M., Moustafa F., Ney B., Nieto J.A., Núñez M.J., Del Carmen Olivares M., Otalora S., Otero R., Pace F., Parisi R., Pedrajas J.M., Pellejero G., Pérez-Ductor C., Pérez-Jacoiste A., Pérez-Rus G., Peris M.L., Pesavento R., Pesce M.L., Porras J.A., Prandoni P., Quintavalla R., Riesco D., Rivas A., Rocci A., Rodríguez-Dávila M.Á., Rodríguez-Hernández A., Rosa V., Rubio C.M., Ruiz-Alcaraz S., Ruiz-Artacho P., Ruiz-Ruiz J., Ruiz-Sada P., Ruiz-Torregrosa P., Sahuquillo J.C., Sala-Sainz C., Salgado E., Sampériz Á., Sánchez-Muñoz-Torrero J.F., Sancho T., Dhayana Sanoja I., Siniscalchi C., Skride A., Soler S., Sotgiu P., Soto M.J., Suriñach J.M., Tafur A., Tiraferri E., Tonello D., Torres M.I., Trujillo-Santos J., Tufano A., Tzoran I., Uresandi F., Usandizaga E., Valle R., Vanassche T., Vandenbriele C., Vázquez F.J., Verhamme P., Vilaseca A., Villalobos A., Visonà A., Vo Hong N., Hyung Bok Yoo H., Zdraveska M.
ISSN
1827-1839 (Electronic)
ISSN-L
0392-9590
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
38
Number
3
Pages
173-184
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Proper risk stratification of patients for early mortality after cancer-associated thrombosis may lead to personalized anticoagulation protocols. Therefore, we aimed to derive and validate a scoring system to predict early mortality in this population. To this end, we selected patients with active cancer and thrombosis from the Computerized Registry of Patients with Venous Thromboembolism database.
The main outcome was all cause mortality within the month following a thrombotic event. We used a simple random selection to split are data in a derivation and a validation cohort. In the derivation cohort, we used recursive partitioning and binary logistic regression to identify groups at risk and to determine the likelihood of the primary outcome. The risk score was developed based on odds ratios from the final multivariate model, and then tested in the validation cohort.
In 10,025 eligible patients, we identified 6 predictors of 30-day mortality: leukocytosis ≥11.5x109/L; platelet count ≤160x109/L, metastasis, recent immobility, initial presentation as pulmonary embolism and Body Mass Index <18.5. The model divided the population into 3 risk categories: low (score 0-3), moderate (score 4-6), and high (score ≥7). The AUC for the overall score was 0.74, and using a cutoff ≥7 points, the model had a negative predictive value of 94.4%, a positive predictive value of 23.1%, a sensitivity of 73.3%, and a specificity of 64.6% in the validation cohort.
Our validated risk model may assist physicians in the selection of patients for outpatient management, and perhaps anticoagulant, considering expanding anticoagulation options.
The main outcome was all cause mortality within the month following a thrombotic event. We used a simple random selection to split are data in a derivation and a validation cohort. In the derivation cohort, we used recursive partitioning and binary logistic regression to identify groups at risk and to determine the likelihood of the primary outcome. The risk score was developed based on odds ratios from the final multivariate model, and then tested in the validation cohort.
In 10,025 eligible patients, we identified 6 predictors of 30-day mortality: leukocytosis ≥11.5x109/L; platelet count ≤160x109/L, metastasis, recent immobility, initial presentation as pulmonary embolism and Body Mass Index <18.5. The model divided the population into 3 risk categories: low (score 0-3), moderate (score 4-6), and high (score ≥7). The AUC for the overall score was 0.74, and using a cutoff ≥7 points, the model had a negative predictive value of 94.4%, a positive predictive value of 23.1%, a sensitivity of 73.3%, and a specificity of 64.6% in the validation cohort.
Our validated risk model may assist physicians in the selection of patients for outpatient management, and perhaps anticoagulant, considering expanding anticoagulation options.
Pubmed
Web of science
Create date
25/05/2019 11:36
Last modification date
26/11/2020 13:10
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