Recognition of Intracellular Bacteria by Inflammasomes.

Détails

ID Serval
serval:BIB_9706BF5CAE4E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Recognition of Intracellular Bacteria by Inflammasomes.
Périodique
Microbiology spectrum
Auteur(s)
Broz P.
ISSN
2165-0497 (Electronic)
ISSN-L
2165-0497
Statut éditorial
Publié
Date de publication
03/2019
Peer-reviewed
Oui
Volume
7
Numéro
2
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Inflammasomes are multiprotein signaling complexes that are assembled by cytosolic sensors upon the detection of infectious or noxious stimuli. These complexes activate inflammatory caspases to induce host cell death and cytokine secretion and are an essential part of antimicrobial host defense. In this review, I discuss how intracellular bacteria are detected by inflammasomes, how the specific sensing mechanism of each inflammasome receptor restricts the ability of bacteria to evade immune recognition, and how host cell death is used to control bacterial replication in vivo.
Mots-clé
Adaptor Proteins, Signal Transducing/metabolism, Animals, Anti-Infective Agents/pharmacology, Apoptosis Regulatory Proteins/metabolism, Bacteria/isolation & purification, Bacteria/pathogenicity, CARD Signaling Adaptor Proteins/metabolism, Calcium-Binding Proteins/metabolism, Cell Death, Cytokines/metabolism, Cytosol/microbiology, DNA-Binding Proteins/metabolism, Humans, Immune Evasion, Inflammasomes/immunology, Inflammasomes/metabolism, NLR Family, Pyrin Domain-Containing 3 Protein/metabolism, Neuronal Apoptosis-Inhibitory Protein/metabolism, Pyrin/metabolism, Pyroptosis/drug effects, Signal Transduction/immunology
Pubmed
Web of science
Création de la notice
08/04/2019 17:59
Dernière modification de la notice
20/08/2019 15:59
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