Measurement of 5-methoxypsoralen and 8-methoxypsoralen in saliva of PUVA patients as a noninvasive, clinically relevant alternative to monitoring in blood

Détails

ID Serval
serval:BIB_96FEEE1662F2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Measurement of 5-methoxypsoralen and 8-methoxypsoralen in saliva of PUVA patients as a noninvasive, clinically relevant alternative to monitoring in blood
Périodique
Archives for Dermatological Research (Archiv fur Dermatologische Forschung)
Auteur(s)
Shephard  S. E., Zogg  M., Burg  G., Panizzon  R. G.
ISSN
0340-3696 (Print)
Statut éditorial
Publié
Date de publication
09/1999
Volume
291
Numéro
9
Pages
491-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
BACKGROUND: Monitoring of psoralen concentration and time-course in PUVA patients is vital for efficient PUVA therapy. Blood sampling is invasive and labour-intensive and thus unsuited for routine use and repeat measurements over the course of therapy. OBJECTIVE: Psoralen pharmacokinetics in saliva were investigated and validated as a noninvasive, simple and biologically relevant alternative to measurements in blood. METHODS: The time-course of psoralen concentration was measured in saliva and serum of volunteers and patients receiving PUVA or extracorporeal photopheresis therapy. The samples were analysed by high-performance liquid chromatography. Three commonly used oral psoralen preparations were tested: Psoraderm5 (5-methoxypsoralen; 5-MOP), Meladinine and Oxsoralen (both 8-methoxypsoralen; 8-MOP). RESULTS: The pharmacokinetic parameter Cmax in saliva averaged 10% (range 6-20%) of the serum values for 8-MOP, and < or = 4% for 5-MOP. These concentrations correspond to the therapeutically relevant, non-albumin-bound fraction of psoralen in serum that is available to diffuse into the tissues. The parameter tmax in saliva and serum coincided, indicating that psoralens diffuse rapidly between the two compartments. CONCLUSION: Monitoring of psoralens in saliva is a valuable, noninvasive alternative to measurements in serum, suitable for routine use. A series of five or six saliva samples is sufficient to determine tmax in a patient beginning photochemotherapy. To determine Cmax, three independent saliva measurements at t = tmax are recommended.
Mots-clé
Adult Feasibility Studies Female Humans Male Methoxsalen/*analogs & derivatives/blood/*pharmacokinetics Middle Aged Osmolar Concentration *PUVA Therapy Reference Values Saliva/*metabolism Sezary Syndrome/drug therapy/metabolism Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 14:58
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