Cortical and Commissural Defects Upon HCF-1 Loss in Nkx2.1-Derived Embryonic Neurons and Glia.

Détails

ID Serval
serval:BIB_96B5A3B59A2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cortical and Commissural Defects Upon HCF-1 Loss in Nkx2.1-Derived Embryonic Neurons and Glia.
Périodique
Developmental neurobiology
Auteur(s)
Minocha S., Herr W.
ISSN
1932-846X (Electronic)
ISSN-L
1932-8451
Statut éditorial
Publié
Date de publication
06/2019
Peer-reviewed
Oui
Volume
79
Numéro
6
Pages
578-595
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Formation of the cerebral cortex and commissures involves a complex developmental process defined by multiple molecular mechanisms governing proliferation of neuronal and glial precursors, neuronal and glial migration, and patterning events. Failure in any of these processes can lead to malformations. Here, we study the role of HCF-1 in these processes. HCF-1 is a conserved metazoan transcriptional co-regulator long implicated in cell proliferation and more recently in human metabolic disorders and mental retardation. Loss of HCF-1 in a subset of ventral telencephalic Nkx2.1-positive progenitors leads to reduced numbers of GABAergic interneurons and glia, owing not to decreased proliferation but rather to increased apoptosis before cell migration. The loss of these cells leads to development of severe commissural and cortical defects in early postnatal mouse brains. These defects include mild and severe structural defects of the corpus callosum and anterior commissure, respectively, and increased folding of the cortex resembling polymicrogyria. Hence, in addition to its well-established role in cell proliferation, HCF-1 is important for organ development, here the brain.
Mots-clé
GABAergic neurons, Nkx2.1, anterior commissure, corpus callosum, cortex, glia, polymicrogyria
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/06/2019 17:55
Dernière modification de la notice
21/08/2019 6:37
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