Densitometer-Specific Differences in the Correlation Between Body Mass Index and Lumbar Spine Trabecular Bone Score.

Détails

ID Serval
serval:BIB_9684D43C9BD3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Densitometer-Specific Differences in the Correlation Between Body Mass Index and Lumbar Spine Trabecular Bone Score.
Périodique
Journal of clinical densitometry
Auteur(s)
Mazzetti G., Berger C., Leslie W.D., Hans D., Langsetmo L., Hanley D.A., Kovacs C.S., Prior J.C., Kaiser S.M., Davison K.S., Josse R., Papaioannou A., Adachi J.R., Goltzman D., Morin S.N.
Collaborateur(s)
CaMos Research Group
ISSN
1094-6950 (Print)
ISSN-L
1094-6950
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
20
Numéro
2
Pages
233-238
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
Trabecular bone score (TBS) is a gray-level texture measure derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images that predicts fractures independent of bone mineral density (BMD). Increased abdominal soft tissue in individuals with elevated body mass index (BMI) absorbs more X-rays during image acquisition for BMD measurement and must be accommodated by the TBS algorithm. We aimed to determine if the relationship between BMI and TBS varied between 2 major manufacturers' densitometers, because different densitometers accommodate soft tissues differently. We identified 1919 women and 811 men, participants of the Canadian Multicentre Osteoporosis Study, aged ≥40 yr with lumbar spine DXA scans acquired on GE Lunar (4 centers) or Hologic (3 centers) densitometers at year 10 of follow-up. TBS was calculated for L1-L4 (TBS iNsight® software, version 2.1). A significant negative correlation between TBS and BMI was observed when TBS measurements were performed on Hologic densitometers in men (Pearson r = -0.36, p <0.0001) and in women (Pearson r = -0.33, p <0.0001); significant correlations were not seen when TBS was measured on GE Lunar densitometers (Pearson r = 0.00 in men, Pearson r = -0.02 in women). Age-adjusted linear regression models confirmed significant interactions between BMI and densitometer manufacturer for both men and women (p < 0.0001). In contrast, comparable positive correlations were observed between BMD and BMI on both Hologic and GE Lunar densitometers in men and women. In conclusion, BMI significantly affects TBS values in men and women when measured on Hologic but not GE Lunar densitometers. This finding has implications for clinical and research applications of TBS, especially when TBS is measured sequentially on DXA densitometers from different manufacturers or when results from different machines are pooled for analysis.
Mots-clé
Absorptiometry, Photon/instrumentation, Aged, Algorithms, Body Mass Index, Bone Density, Cancellous Bone/diagnostic imaging, Female, Humans, Lumbar Vertebrae/diagnostic imaging, Male, Middle Aged, Body mass index, bone mineral density, cohort study, densitometer, trabecular bone score
Pubmed
Web of science
Création de la notice
10/01/2017 18:40
Dernière modification de la notice
20/08/2019 14:58
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