Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury

Details

Serval ID
serval:BIB_95FBEBFC11D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury
Journal
American Review of Respiratory Disease
Author(s)
Gilliard  N., Richman  P. M., Merritt  T. A., Spragg  R. G.
ISSN
0003-0805 (Print)
Publication state
Published
Issued date
03/1990
Volume
141
Number
3
Pages
743-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Abstract
Administration of exogenous lung surfactant to infants with or at risk for respiratory distress syndrome has been demonstrated to improve gas exchange and survival; administration of surfactant to patients with the adult respiratory distress syndrome is currently undergoing clinical evaluation. Although it is currently assumed the optimal effect will occur when administered surfactant is distributed homogeneously throughout the lung, little is known of the influence of variables inherent in the administration procedure on subsequent distribution. To address this question, we studied the effect of the volume size in which the surfactant is suspended for instillation, and demonstrated a marked relationship in the normal rabbit lung between this volume and the subsequent homogeneity of surfactant distribution. In the rabbit lung that was acutely injured by oleic acid, this relationship was not evident. Concentration of administered surfactant was not demonstrated to be of major influence on its distribution after administration. Our results focus attention on the importance of parameters of the administration procedure, and also demonstrate the usefulness of the techniques used for determination of surfactant distribution.
Keywords
Animals Injections, Intra-Arterial Instillation, Drug Lung/drug effects/*metabolism/pathology Lung Compliance Oleic Acids/*adverse effects Phospholipids/analysis Pulmonary Edema/chemically induced/metabolism Pulmonary Surfactants/*administration & dosage/analysis/pharmacokinetics Rabbits Tissue Distribution
Pubmed
Web of science
Create date
28/01/2008 10:50
Last modification date
20/08/2019 14:58
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