Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project.

Détails

ID Serval
serval:BIB_95F8890DDD43
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project.
Périodique
Hypertension
Auteur(s)
Tabara Y., Kohara K., Kita Y., Hirawa N., Katsuya T., Ohkubo T., Hiura Y., Tajima A., Morisaki T., Miyata T., Nakayama T., Takashima N., Nakura J., Kawamoto R., Takahashi N., Hata A., Soma M., Imai Y., Kokubo Y., Okamura T., Tomoike H., Iwai N., Ogihara T., Inoue I., Tokunaga K., Johnson T., Caulfield M., Munroe P., Umemura S., Umemura S., Ueshima H., Miki T.
Collaborateur(s)
Global Blood Pressure Genetics Consortium
Contributeur(s)
Newton-Cheh C., Johnson T., Gateva V., Tobin MD., Bochud M., Coin L., Najjar SS., Zhao JH., Heath SC., Eyheramendy S., Papadakis K., Voight BF., Scott LJ., Zhang F., Farrall M., Tanaka T., Wallace C., Chambers JC., Khaw KT., Nilsson P., van der Harst P., Polidoro S., Grobbee DE., Onland-Moret NC., Bots ML., Wain LV., Elliott KS., Teumer A., Luan£££Jian'an£££ J. , Lucas G., Kuusisto J., Burton PR., Hadley D., McArdle WL., Brown M., Dominiczak A., Newhouse SJ., Samani NJ., Webster J., Zeggini E., Beckmann JS., Bergmann S., Lim N., Song K., Vollenweider P., Waeber G., Waterworth DM., Yuan X., Groop L., Orho-Melander M., Allione A., Di Gregorio A., Guarrera S., Panico S., Ricceri F., Romanazzi V., Sacerdote C., Vineis P., Barroso£££Inês£££ I. , Sandhu MS., Luben RN., Crawford GJ., Jousilahti P., Perola M., Boehnke M., Bonnycastle LL., Collins FS., Jackson AU., Mohlke KL., Stringham HM., Valle TT., Willer CJ., Bergman RN., Morken MA., Döring A., Gieger C., Illig T., Meitinger T., Org E., Pfeufer A., Wichmann HE., Kathiresan S., Marrugat J., O'Donnell CJ., Schwartz SM., Siscovick DS., Subirana I., Freimer NB., Hartikainen AL., McCarthy MI., O'Reilly PF., Peltonen L., Pouta A., de Jong PE. , Snieder H., van Gilst WH. , Clarke R., Goel A., Hamsten A., Peden JF., Seedorf U., Syvänen AC., Tognoni G., Lakatta EG., Sanna S., Scheet P., Schlessinger D., Scuteri A., Dörr M., Ernst F., Felix SB., Homuth G., Lorbeer R., Reffelmann T., Rettig R., Völker U., Galan P., Gut IG., Hercberg S., Lathrop GM., Zeleneka D., Deloukas P., Soranzo N., Williams FM., Zhai G., Salomaa V., Laakso M., Elosua R., Forouhi NG., Völzke H., Uiterwaal CS., van der Schouw YT. , Numans ME., Matullo G., Navis G., Berglund G., Bingham SA., Kooner JS., Connell JM., Bandinelli S., Ferrucci L., Watkins H., Spector TD., Tuomilehto J., Altshuler D., Strachan DP., Laan M., Meneton P., Wareham NJ., Uda M., Jarvelin MR., Mooser V., Melander O., Loos RJ., Elliott P., Abecasis GR., Caulfield M., Munroe PB.
ISSN
1524-4563 (Electronic)
ISSN-L
0194-911X
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
56
Numéro
5
Pages
973-980
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association with hypertension in Japanese individuals. In this study we extend our previous findings by analyzing a large sample of Japanese individuals (n=14 105) for the most associated SNPs. We also conducted replication analyses in Japanese of susceptibility loci for hypertension identified recently from genome-wide association studies of European ancestries. Association analysis revealed significant association of the ATP2B1 rs2070759 polymorphism with hypertension (P=5.3×10(-5); allelic odds ratio: 1.17 [95% CI: 1.09 to 1.26]). Additional SNPs in ATP2B1 were subsequently genotyped, and the most significant association was with rs11105378 (odds ratio: 1.31 [95% CI: 1.21 to 1.42]; P=4.1×10(-11)). Association of rs11105378 with hypertension was cross-validated by replication analysis with the Global Blood Pressure Genetics consortium data set (odds ratio: 1.13 [95% CI: 1.05 to 1.21]; P=5.9×10(-4)). Mean adjusted systolic blood pressure was highly significantly associated with the same SNP in a meta-analysis with individuals of European descent (P=1.4×10(-18)). ATP2B1 mRNA expression levels in umbilical artery smooth muscle cells were found to be significantly different among rs11105378 genotypes. Seven SNPs discovered in published genome-wide association studies were also genotyped in the Japanese population. In the combined analysis with replicated 3 genes, FGF5 rs1458038, CYP17A1, rs1004467, and CSK rs1378942, odds ratio of the highest risk group was 2.27 (95% CI: 1.65 to 3.12; P=4.6×10(-7)) compared with the lower risk group. In summary, this study confirmed common genetic variation in ATP2B1, as well as FGF5, CYP17A1, and CSK, to be associated with blood pressure levels and risk of hypertension.
Mots-clé
Alleles, Analysis of Variance, Asian Continental Ancestry Group/genetics, Case-Control Studies, Gene Frequency, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Hypertension/genetics, Odds Ratio, Plasma Membrane Calcium-Transporting ATPases/genetics, Polymorphism, Single Nucleotide, Regression Analysis
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/12/2010 12:15
Dernière modification de la notice
08/05/2019 22:18
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