Evolution of novel metabolic pathways for the degradation of chloroaromatic compounds.

Détails

ID Serval
serval:BIB_95E7F218FB1A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Evolution of novel metabolic pathways for the degradation of chloroaromatic compounds.
Périodique
Antonie van Leeuwenhoek
Auteur(s)
van der Meer J.R.
ISSN
0003-6072 (Print)
ISSN-L
0003-6072
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
71
Numéro
1-2
Pages
159-178
Langue
anglais
Résumé
Chlorobenzenes are substrates not easily metabolized by existing bacteria in the environment. Specific strains, however, have been isolated from polluted environments or in laboratory selection procedures that use chlorobenzenes as their sole carbon and energy source. Genetic analysis indicated that these bacteria have acquired a novel combination of previously existing genes. One of these gene clusters contains the genes for an aromatic ring dioxygenase and a dihydrodiol dehydrogenase. The other contains the genes for a chlorocatechol oxidative pathway. Comparison of such gene clusters with those from other aromatics degrading bacteria reveals that this process of recombining or assembly of existing genetic material must have occurred in many of them. Similarities of gene functions between pathways suggest the incorporation of existing genetic material has been the most important mechanism of expanding a metabolic pathway. Only in a few cases a horizontal expansion, that is acquisition of gene functions to accommodate a wider range of substrates which are then all transformed in one central pathway, is observed on the genetic level. Evidence is presented indicating that the assembly process may trigger a faster divergence of nearby gene sequences. Further 'fine-tuning', for example by developing a proper regulation, is then the next step in the adaptation.
Mots-clé
Adaptation, Physiological, Bacteria, Aerobic/genetics, Bacteria, Aerobic/metabolism, Base Sequence, Biodegradation, Environmental, Chlorobenzenes/metabolism, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hydrocarbons, Chlorinated/metabolism, Mixed Function Oxygenases/metabolism, Molecular Sequence Data, Oxygenases/metabolism
Pubmed
Web of science
Création de la notice
21/01/2008 14:35
Dernière modification de la notice
03/03/2018 19:41
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