An unusual uterine tumour with signet ring cell features

Détails

ID Serval
serval:BIB_95D7A46274C8
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
An unusual uterine tumour with signet ring cell features
Titre de la conférence
22nd European Congress of Pathology
Auteur(s)
Rossella S., Fiche M., Achtari C., Ketterer N., de Laval L.
Adresse
Florence, Italy, September 4-9, 2009
ISBN
0945-6317
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
457
Série
Virchows Archiv
Pages
195
Langue
anglais
Notes
Meeting Abstract
Résumé
Objective: Lymphomas with signet ring cell features are
rare, as is uterine dissemination of lymphomas. We report
an exceptional case of a uterine tumor combining these two
characteristics.
Method: A 61-year-old female was diagnosed in 2004 with
localized nodal grade 2 follicular lymphoma (stage IA). She
received local radiation therapy, experienced total remission,
and did well until 2009 when a systematic CT scan
evidenced a pelvic anterior-lateral mass. Total enlarged
hysterectomy was performed.
Results: The anterior uterine wall contained a 4.8-cm fish
flesh well-delineated mass corresponding to a mostly
diffuse and focally nodular proliferation of medium to
large cells with extensive signet ring cell changes. Tumor
cells were CD20-, CD10-, Bcl2-, and Bcl6-positive with a
low proliferation rate (<10-15%); CD21 underlined a focal
follicular architecture. The vacuoles were PAS-negative and
did not stain for immunoglobulin; ultrastructural analysis
revealed nonspecific degenerative vacuoles. No lymph
nodes were identified isolated from the surgical specimen.
The tumor was considered as a secondary localization of
the systemic follicular lymphoma, though no signet ring
cells were evidenced in the cervical lymph node biopsy
(reviewed). Follow-up showed retroperitoneal tissue infiltration
(PET-CT) and normal medullar biopsy. She recently
started R-CHOP chemotherapy.
Conclusion: This case illustrates both an unusual site of
dissemination and challenging cytological characteristics in
a follicular lymphoma. The signet ring cell changes
challenged the adequate classification of this lymphoma as
either a large B cell or a follicular B cell lymphoma.
Web of science
Création de la notice
01/09/2010 9:23
Dernière modification de la notice
03/03/2018 19:41
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