Initial sequencing and comparative analysis of the mouse genome.

Waterston, R.H.; Waterston, R.H.; Lindblad-Toh, K.; Birney, E.; Rogers, J.; Abril, J.F.; Agarwal, P.; Agarwala, R.; Ainscough, R.; Alexandersson, M.; An, P.; Antonarakis, S.E.; Attwood, J.; Baertsch, R.; Bailey, J.; Barlow, K.; Beck, S.; Berry, E.; Birren, B.; Bloom, T.; Bork, P.; Botcherby, M.; Bray, N.; Brent, M.R.; Brown, D.G.; Brown, S.D.; Bult, C.; Burton, J.; Butler, J.; Campbell, R.D.; Carninci, P.; Cawley, S.; Chiaromonte, F.; Chinwalla, A.T.; Church, D.M.; Clamp, M.; Clee, C.; Collins, F.S.; Cook, L.L.; Copley, R.R.; Coulson, A.; Couronne, O.; Cuff, J.; Curwen, V.; Cutts, T.; Daly, M.; David, R.; Davies, J.; Delehaunty, K.D.; Deri, J.; Dermitzakis, E.T.; Dewey, C.; Dickens, N.J.; Diekhans, M.; Dodge, S.; Dubchak, I.; Dunn, D.M.; Eddy, S.R.; Elnitski, L.; Emes, R.D.; Eswara, P.; Eyras, E.; Felsenfeld, A.; Fewell, G.A.; Flicek, P.; Foley, K.; Frankel, W.N.; Fulton, L.A.; Fulton, R.S.; Furey, T.S.; Gage, D.; Gibbs, R.A.; Glusman, G.; Gnerre, S.; Goldman, N.; Goodstadt, L.; Grafham, D.; Graves, T.A.; Green, E.D.; Gregory, S.; Guigó, R.; Guyer, M.; Hardison, R.C.; Haussler, D.; Hayashizaki, Y.; Hillier, L.W.; Hinrichs, A.; Hlavina, W.; Holzer, T.; Hsu, F.; Hua, A.; Hubbard, T.; Hunt, A.; Jackson, I.; Jaffe, D.B.; Johnson, L.S.; Jones, M.; Jones, T.A.; Joy, A.; Kamal, M.; Karlsson, E.K.; Karolchik, D.; Kasprzyk, A.; Kawai, J.; Keibler, E.; Kells, C.; Kent, W.J.; Kirby, A.; Kolbe, D.L.; Korf, I.; Kucherlapati, R.S.; Kulbokas, E.J.; Kulp, D.; Landers, T.; Leger, J.P.; Leonard, S.; Letunic, I.; Levine, R.; Li, J.; Li, M.; Lloyd, C.; Lucas, S.; Ma, B.; Maglott, D.R.; Mardis, E.R.; Matthews, L.; Mauceli, E.; Mayer, J.H.; McCarthy, M.; McCombie, W.R.; McLaren, S.; McLay, K.; McPherson, J.D.; Meldrim, J.; Meredith, B.; Mesirov, J.P.; Miller, W.; Miner, T.L.; Mongin, E.; Montgomery, K.T.; Morgan, M.; Mott, R.; Mullikin, J.C.; Muzny, D.M.; Nash, W.E.; Nelson, J.O.; Nhan, M.N.; Nicol, R.; Ning, Z.; Nusbaum, C.; O'Connor, M.J.; Okazaki, Y.; Oliver, K.; Overton-Larty, E.; Pachter, L.; Parra, G.; Pepin, K.H.; Peterson, J.; Pevzner, P.; Plumb, R.; Pohl, C.S.; Poliakov, A.; Ponce, T.C.; Ponting, C.P.; Potter, S.; Quail, M.; Reymond, A.; Roe, B.A.; Roskin, K.M.; Rubin, E.M.; Rust, A.G.; Santos, R.; Sapojnikov, V.; Schultz, B.; Schultz, J.; Schwartz, M.S.; Schwartz, S.; Scott, C.; Seaman, S.; Searle, S.; Sharpe, T.; Sheridan, A.; Shownkeen, R.; Sims, S.; Singer, J.B.; Slater, G.; Smit, A.; Smith, D.R.; Spencer, B.; Stabenau, A.; Stange-Thomann, N.; Sugnet, C.; Suyama, M.; Tesler, G.; Thompson, J.; Torrents, D.; Trevaskis, E.; Tromp, J.; Ucla, C.; Ureta-Vidal, A.; Vinson, J.P.; Von Niederhausern, A.C.; Wade, C.M.; Wall, M.; Weber, R.J.; Weiss, R.B.; Wendl, M.C.; West, A.P.; Wetterstrand, K.; Wheeler, R.; Whelan, S.; Wierzbowski, J.; Willey, D.; Williams, S.; Wilson, R.K.; Winter, E.; Worley, K.C.; Wyman, D.; Yang, S.; Yang, S.P.; Zdobnov, E.M.; Zody, M.C.; Lander, E.S.

doi:10.1038/nature01262

Initial sequencing and comparative analysis of the mouse genome.

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Serval ID

serval:BIB_959C275EBB0C

Type

Article: article from journal or magazin.

Collection

Publications

Institution

Production externe

Title

Initial sequencing and comparative analysis of the mouse genome.

Journal

Nature

Author(s)

Waterston R.H., Waterston R.H., Lindblad-Toh K., Birney E., Rogers J., Abril J.F., Agarwal P., Agarwala R., Ainscough R., Alexandersson M., An P., Antonarakis S.E., Attwood J., Baertsch R., Bailey J., Barlow K., Beck S., Berry E., Birren B., Bloom T., Bork P., Botcherby M., Bray N., Brent M.R., Brown D.G., Brown S.D., Bult C., Burton J., Butler J., Campbell R.D., Carninci P., Cawley S., Chiaromonte F., Chinwalla A.T., Church D.M., Clamp M., Clee C., Collins F.S., Cook L.L., Copley R.R., Coulson A., Couronne O., Cuff J., Curwen V., Cutts T., Daly M., David R., Davies J., Delehaunty K.D., Deri J., Dermitzakis E.T., Dewey C., Dickens N.J., Diekhans M., Dodge S., Dubchak I., Dunn D.M., Eddy S.R., Elnitski L., Emes R.D., Eswara P., Eyras E., Felsenfeld A., Fewell G.A., Flicek P., Foley K., Frankel W.N., Fulton L.A., Fulton R.S., Furey T.S., Gage D., Gibbs R.A., Glusman G., Gnerre S., Goldman N., Goodstadt L., Grafham D., Graves T.A., Green E.D., Gregory S., Guigó R., Guyer M., Hardison R.C., Haussler D., Hayashizaki Y., Hillier L.W., Hinrichs A., Hlavina W., Holzer T., Hsu F., Hua A., Hubbard T., Hunt A., Jackson I., Jaffe D.B., Johnson L.S., Jones M., Jones T.A., Joy A., Kamal M., Karlsson E.K., Karolchik D., Kasprzyk A., Kawai J., Keibler E., Kells C., Kent W.J., Kirby A., Kolbe D.L., Korf I., Kucherlapati R.S., Kulbokas E.J., Kulp D., Landers T., Leger J.P., Leonard S., Letunic I., Levine R., Li J., Li M., Lloyd C., Lucas S., Ma B., Maglott D.R., Mardis E.R., Matthews L., Mauceli E., Mayer J.H., McCarthy M., McCombie W.R., McLaren S., McLay K., McPherson J.D., Meldrim J., Meredith B., Mesirov J.P., Miller W., Miner T.L., Mongin E., Montgomery K.T., Morgan M., Mott R., Mullikin J.C., Muzny D.M., Nash W.E., Nelson J.O., Nhan M.N., Nicol R., Ning Z., Nusbaum C., O'Connor M.J., Okazaki Y., Oliver K., Overton-Larty E., Pachter L., Parra G., Pepin K.H., Peterson J., Pevzner P., Plumb R., Pohl C.S., Poliakov A., Ponce T.C., Ponting C.P., Potter S., Quail M., Reymond A., Roe B.A., Roskin K.M., Rubin E.M., Rust A.G., Santos R., Sapojnikov V., Schultz B., Schultz J., Schwartz M.S., Schwartz S., Scott C., Seaman S., Searle S., Sharpe T., Sheridan A., Shownkeen R., Sims S., Singer J.B., Slater G., Smit A., Smith D.R., Spencer B., Stabenau A., Stange-Thomann N., Sugnet C., Suyama M., Tesler G., Thompson J., Torrents D., Trevaskis E., Tromp J., Ucla C., Ureta-Vidal A., Vinson J.P., Von Niederhausern A.C., Wade C.M., Wall M., Weber R.J., Weiss R.B., Wendl M.C., West A.P., Wetterstrand K., Wheeler R., Whelan S., Wierzbowski J., Willey D., Williams S., Wilson R.K., Winter E., Worley K.C., Wyman D., Yang S., Yang S.P., Zdobnov E.M., Zody M.C., Lander E.S.

Working group(s)

Mouse Genome Sequencing Consortium

ISSN

0028-0836 (Print)

ISSN-L

0028-0836

Publication state

Published

Issued date

2002

Volume

420

Number

6915

Pages

520-562

Language

english

Abstract

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

Keywords

Animals, Base Composition, Chromosomes, Mammalian/genetics, Conserved Sequence/genetics, CpG Islands/genetics, Evolution, Molecular, Gene Expression Regulation, Genes/genetics, Genetic Variation/genetics, Genome, Genome, Human, Genomics, Humans, Mice/classification, Mice/genetics, Mice, Knockout, Mice, Transgenic, Models, Animal, Multigene Family/genetics, Mutagenesis, Neoplasms/genetics, Physical Chromosome Mapping, Proteome/genetics, Pseudogenes/genetics, Quantitative Trait Loci/genetics, RNA, Untranslated/genetics, Repetitive Sequences, Nucleic Acid/genetics, Selection, Genetic, Sequence Analysis, DNA, Sex Chromosomes/genetics, Species Specificity, Synteny

DOI

10.1038/nature01262

Pubmed

12466850

Web of science

000179611600053

Open Access

Yes

Create date

24/01/2008 16:52

Last modification date

20/08/2019 15:57

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Initial sequencing and comparative analysis of the mouse genome.

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