Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes

Détails

ID Serval
serval:BIB_95441CD60400
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes
Périodique
FEBS Letters
Auteur(s)
Cao  Y., Chatton  J. Y.
ISSN
0014-5793 (Print)
Statut éditorial
Publié
Date de publication
03/1998
Volume
424
Numéro
1-2
Pages
33-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 6
Résumé
The possible participation of calmodulin in the activation of store-operated Ca2+ entry (SOC) in single rat hepatocytes was investigated microspectrofluorimetrically. SOC was triggered after discharging intracellular Ca2+ stores using the endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin in the absence of external Ca2+. Re-admission of bath Ca2+ caused a rapid and pronounced Ca2+ entry. The calmodulin antagonists calmidazolium or CGS 9343B applied before the thapsigargin treatment inhibited SOC, whereas they were ineffective when added after the thapsigargin-induced Ca2+ transient. This study suggests that activation of calmodulin after the elevation of cytosolic Ca2+ associated with the emptying of Ca2+ stores is involved in the triggering of SOC in hepatocytes.
Mots-clé
Animals Calcium/*metabolism Calcium-Transporting ATPases/*antagonists & inhibitors Calmodulin/antagonists & inhibitors/*metabolism Enzyme Inhibitors/pharmacology Imidazoles/pharmacology Liver/cytology/*metabolism Male Rats Rats, Wistar Signal Transduction Thapsigargin/pharmacology
Pubmed
Web of science
Création de la notice
24/01/2008 14:08
Dernière modification de la notice
03/03/2018 19:39
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