Comparative modular analysis of gene expression in vertebrate organs.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_94FEE072331D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparative modular analysis of gene expression in vertebrate organs.
Périodique
Bmc Genomics
Auteur(s)
Piasecka B., Kutalik Z., Roux J., Bergmann S., Robinson-Rechavi M.
ISSN
1471-2164 (Electronic)
ISSN-L
1471-2164
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
13
Pages
124
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
ABSTRACT:
BACKGROUND: The degree of conservation of gene expression between homologous organs largely remains an open question. Several recent studies reported some evidence in favor of such conservation. Most studies compute organs' similarity across all orthologous genes, whereas the expression level of many genes are not informative about organ specificity.
RESULTS: Here, we use a modularization algorithm to overcome this limitation through the identification of inter-species co-modules of organs and genes. We identify such co-modules using mouse and human microarray expression data. They are functionally coherent both in terms of genes and of organs from both organisms. We show that a large proportion of genes belonging to the same co-module are orthologous between mouse and human. Moreover, their zebrafish orthologs also tend to be expressed in the corresponding homologous organs. Notable exceptions to the general pattern of conservation are the testis and the olfactory bulb. Interestingly, some co-modules consist of single organs, while others combine several functionally related organs. For instance, amygdala, cerebral cortex, hypothalamus and spinal cord form a clearly discernible unit of expression, both in mouse and human.
CONCLUSIONS: Our study provides a new framework for comparative analysis which will be applicable also to other sets of large-scale phenotypic data collected across different species.
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/03/2012 9:38
Dernière modification de la notice
08/05/2019 22:15
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