YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma.
Details
Serval ID
serval:BIB_94EF85011B9B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma.
Journal
Annals of Neurology
ISSN
1531-8249 (Electronic)
ISSN-L
0364-5134
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
70
Number
1
Pages
163-169
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: To evaluate YKL-40 and MMP-9 proteins as tumor biomarkers in serum samples from patients with primary central nervous system lymphoma (PCNSL).
METHODS: In this prospective longitudinal study, serum samples from consecutive patients with histologically confirmed PCNSL were collected concurrently with magnetic resonance imaging (MRI) scans at multiple time points and were analyzed for levels of YKL-40 and MMP-9 by enzyme-linked immunosorbent assay. Marker levels were correlated to disease status and survival.
RESULTS: Forty-five patients with PCNSL were accrued. Median follow-up for survivors was 25 months, and 21 (47%) died during the study. A total of 230 serum samples were collected, and 93% had corresponding MRI scans. PCNSL patients without evidence of radiographic disease (29 patients, 131 samples) had significantly lower levels of serum YKL-40 and MMP-9 than patients with active tumor (n = 34 patients, 84 samples; p = 0.03 and 0.01, respectively). There was a significant inverse correlation between survival and doubling of the YKL-40 level (hazard ratio, 1.7; p = 0.01).
INTERPRETATION: In patients with PCNSL, serum levels of YKL-40 and MMP-9 are associated with radiographic disease status. Longitudinal increase in serum levels of YKL-40, but not MMP-9, predicts survival in patients with PCNSL.
METHODS: In this prospective longitudinal study, serum samples from consecutive patients with histologically confirmed PCNSL were collected concurrently with magnetic resonance imaging (MRI) scans at multiple time points and were analyzed for levels of YKL-40 and MMP-9 by enzyme-linked immunosorbent assay. Marker levels were correlated to disease status and survival.
RESULTS: Forty-five patients with PCNSL were accrued. Median follow-up for survivors was 25 months, and 21 (47%) died during the study. A total of 230 serum samples were collected, and 93% had corresponding MRI scans. PCNSL patients without evidence of radiographic disease (29 patients, 131 samples) had significantly lower levels of serum YKL-40 and MMP-9 than patients with active tumor (n = 34 patients, 84 samples; p = 0.03 and 0.01, respectively). There was a significant inverse correlation between survival and doubling of the YKL-40 level (hazard ratio, 1.7; p = 0.01).
INTERPRETATION: In patients with PCNSL, serum levels of YKL-40 and MMP-9 are associated with radiographic disease status. Longitudinal increase in serum levels of YKL-40, but not MMP-9, predicts survival in patients with PCNSL.
Keywords
Adipokines, Adult, Aged, Aged, 80 and over, Central Nervous System Neoplasms/blood, Central Nervous System Neoplasms/diagnosis, Female, Glycoproteins/blood, Humans, Lectins/blood, Longitudinal Studies, Lymphoma, Non-Hodgkin/blood, Lymphoma, Non-Hodgkin/diagnosis, Male, Matrix Metalloproteinase 9/blood, Middle Aged, Prospective Studies, Tumor Markers, Biological/blood, Tumor Markers, Biological/metabolism, Young Adult
Pubmed
Create date
19/02/2014 22:27
Last modification date
20/08/2019 15:57
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