The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models.

Détails

Ressource 1Télécharger: 12967_2016_Article_1086.pdf (1177.73 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_94B7CF25CA4B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models.
Périodique
Journal of translational medicine
Auteur(s)
Boubred F., Daniel L., Buffat C., Tsimaratos M., Oliver C., Lelièvre-Pégorier M., Simeoni U.
ISSN
1479-5876 (Electronic)
ISSN-L
1479-5876
Statut éditorial
Publié
Date de publication
30/11/2016
Peer-reviewed
Oui
Volume
14
Numéro
1
Pages
331
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish

Résumé
Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT and CRD are linked to the magnitude of nephron number reduction, independently on its cause.
Systolic blood pressure (SBP), glomerular filtration rate (GFR), proteinuria, nephron number, and glomerular sclerosis were compared between IUGR offspring prenatally exposed to a maternal low-protein diet (9% casein; LPD offspring) or maternal administration of betamethasone (from E17 to E19; BET offspring) and offspring with a normal birth weight (NBW offspring).
Both prenatal interventions led to IUGR and a similar reduction in birth weight. In comparison to NBW offspring, BET offspring had a severe nephron deficit (-50% in males and -40% in females, p < 0.01), an impaired GFR (-33%, p < 0.05), and HT (SBP+ 17 mmHg, p < 0.05). Glomerular sclerosis was more than twofold higher in BET offspring than in NBW offspring (p < 0.05). Long-term SBP, GFR, and glomerular sclerosis were unchanged in LPD offspring while the nephron number was moderately reduced only in males (-28% vs. NBW offspring, p < 0.05).
In this study, the magnitude of nephron number reduction influences long term renal disease in IUGR offspring: a moderate nephron number is an insufficient factor. Extremely long-term follow-up of adults prenatally exposed to glucocorticoids are required.

Pubmed
Web of science
Open Access
Oui
Création de la notice
12/12/2016 21:36
Dernière modification de la notice
08/05/2019 22:14
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