OpenFluDB, a database for human and animal influenza virus.

Détails

Ressource 1Télécharger: 20624713_BIB_949FEEAB2750.pdf (1156.50 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_949FEEAB2750
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
OpenFluDB, a database for human and animal influenza virus.
Périodique
Database
Auteur(s)
Liechti R., Gleizes A., Kuznetsov D., Bougueleret L., Le Mercier P., Bairoch A., Xenarios I.
ISSN
1758-0463 (Electronic)
Statut éditorial
Publié
Date de publication
2010
Volume
2010
Pages
baq004
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Although research on influenza lasted for more than 100 years, it is still one of the most prominent diseases causing half a million human deaths every year. With the recent observation of new highly pathogenic H5N1 and H7N7 strains, and the appearance of the influenza pandemic caused by the H1N1 swine-like lineage, a collaborative effort to share observations on the evolution of this virus in both animals and humans has been established. The OpenFlu database (OpenFluDB) is a part of this collaborative effort. It contains genomic and protein sequences, as well as epidemiological data from more than 27,000 isolates. The isolate annotations include virus type, host, geographical location and experimentally tested antiviral resistance. Putative enhanced pathogenicity as well as human adaptation propensity are computed from protein sequences. Each virus isolate can be associated with the laboratories that collected, sequenced and submitted it. Several analysis tools including multiple sequence alignment, phylogenetic analysis and sequence similarity maps enable rapid and efficient mining. The contents of OpenFluDB are supplied by direct user submission, as well as by a daily automatic procedure importing data from public repositories. Additionally, a simple mechanism facilitates the export of OpenFluDB records to GenBank. This resource has been successfully used to rapidly and widely distribute the sequences collected during the recent human swine flu outbreak and also as an exchange platform during the vaccine selection procedure. Database URL: http://openflu.vital-it.ch.
Mots-clé
Animals, Birds, Databases, Genetic, Evolution, Molecular, Genome, Viral, Humans, Influenza A Virus, H1N1 Subtype/genetics, Influenza A Virus, H1N1 Subtype/isolation & purification, Influenza in Birds/virology, Influenza, Human/virology, Orthomyxoviridae/genetics, Orthomyxoviridae/isolation & purification, Orthomyxoviridae Infections/virology, Phylogeny, Sequence Alignment/statistics & numerical data, Swine, User-Computer Interface
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/03/2011 12:33
Dernière modification de la notice
20/08/2019 14:57
Données d'usage