Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females.

Details

Serval ID
serval:BIB_949EFBCDDE78
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females.
Journal
Journal of invertebrate pathology
Author(s)
Basu A., Singh A., Sehgal S., Madaan T., Prasad N.G.
ISSN
1096-0805 (Electronic)
ISSN-L
0022-2011
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Defense against pathogens and parasites requires substantial investment of energy and resources on part of the host. This makes the host immune function dependent on availability and accessibility of resources. A resource deprived host is therefore expected to be more susceptible to infections, although empirical results do not always align with this prediction. Limiting host access to resources can additionally impact within-host pathogen numbers, either directly by altering the amount of resources available to the pathogens for proliferation or indirectly by altering the efficiency of the host immune system. We tested for the effects of host starvation (complete deprivation of resources) on susceptibility to bacterial pathogens, and within-host pathogen proliferation, in Drosophila melanogaster females. Our results show that starvation increases post-infection mortality of the host, but in a pathogen-specific manner. This increase in mortality is always accompanied by increased within-host pathogen proliferation. We therefore propose that starvation compromises host resistance to bacterial infections in Drosophila melanogaster females thereby increasing susceptibility to infections.
Keywords
Bacterial pathogens, Eco-immunology, Post-infection survival, Resource limitation, Starvation, Within-host pathogen dynamics
Pubmed
Create date
30/09/2024 14:08
Last modification date
01/10/2024 6:09
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