Autophagy induction does not protect retina against apoptosis in ischemia/reperfusion model.

Détails

ID Serval
serval:BIB_9431B272BE4D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Autophagy induction does not protect retina against apoptosis in ischemia/reperfusion model.
Périodique
Advances In Experimental Medicine and Biology
Auteur(s)
Produit-Zengaffinen N., Pournaras C.J., Schorderet D.F.
ISSN
0065-2598 (Print)
ISSN-L
0065-2598
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
801
Pages
677-683
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The role played by autophagy after ischemia/reperfusion (I/R) in the retina remains unknown. Our study investigated whether ischemic injury in the retina, which causes an energy crisis, would induce autophagy. Retinal ischemia was induced by elevation of the intraocular pressure and modulation of autophagic markers was analyzed at the protein levels in an early and late phase of recovery. Following retinal ischemia an increase in LC3BII was first observed in the early phase of recovery but did not stay until the late phase of recovery. Post-ischemic induction of autophagy by intravitreal rapamycin administration did not provide protection against the lesion induced by the ischemic stress. On the contrary, an increase in the number of apoptotic cells was observed following I/R in the rapamycin treated retinas.
Pubmed
Web of science
Création de la notice
07/04/2014 11:28
Dernière modification de la notice
19/03/2018 10:52
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