Targeting the Wnt pathways for therapies

Détails

Ressource 1Télécharger: BIB_9410B64D2CF5.P001.pdf (833.85 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_9410B64D2CF5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Targeting the Wnt pathways for therapies
Périodique
Molecular and Cellular Therapies
Auteur(s)
Blagodatski A., Poteryaev D., Katanaev V.L.
ISSN
2052-8426 (Electronic)
ISSN-L
2052-8426
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
2
Pages
28
Langue
anglais
Notes
Publication types: Review ; review-article Identifiant PubMed Central: PMC4452063
Résumé
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely, improper activation of this pathway is carcinogenic in many tissues, most notably in the colon, liver and the breast. On the other hand, the Wnt/β-catenin signaling must be re-activated in cases of tissue damage, and insufficient activation results in regeneration failure and degeneration. These both medically important implications are unified by the emerging importance of this signaling pathway in the control of proliferation of various types of stem cells, crucial for tissue regeneration and, in case of cancer stem cells - cancer progression and relapse. This article aims at briefly reviewing the current state of knowledge in the field of Wnt signaling, followed by a detailed discussion of current medical developments targeting distinct branches of the Wnt pathway for anti-cancer and pro-regeneration therapies.
Mots-clé
Wnt, Frizzled, Cancer, Regeneration, Drug discovery
Pubmed
Open Access
Oui
Création de la notice
11/07/2016 11:04
Dernière modification de la notice
08/05/2019 22:12
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