Article: article from journal or magazin.
Homocysteate and homocysteine sulfinate, excitatory transmitter candidates present in rat astroglial cultures.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The presence of homocysteate and homocysteine sulfinate was demonstrated in extracts prepared from cultures of rat cortical and cerebellar astrocytes as well as from C6 glioblastoma cells by o-phthalaldehyde derivatization and subsequent HPLC analysis. Homocysteate-like immunoreactivity was found in cultured cortical astrocytes by postembedding immunocytochemistry at the level of light microscopy. These findings support the notion of a glial localization of the excitatory transmitter candidate homocysteate.
Animals, Animals, Newborn/physiology, Astrocytes/chemistry, Astrocytes/metabolism, Bucladesine/metabolism, Chromatography, High Pressure Liquid, Female, Homocysteine/analogs & derivatives, Homocysteine/metabolism, Immunohistochemistry, Neuroglia/chemistry, Neuroglia/metabolism, Neurotransmitter Agents/metabolism, Pregnancy, Rats
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