Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation.

Détails

Ressource 1Télécharger: txd-3-e149.pdf (310.31 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_93FCCAF72C8C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation.
Périodique
Transplantation direct
Auteur(s)
van Heeswijk R.B., Piccini D., Tozzi P., Rotman S., Meyer P., Schwitter J., Stuber M., Hullin R.
ISSN-L
2373-8731
Statut éditorial
Publié
Date de publication
04/2017
Peer-reviewed
Oui
Volume
3
Numéro
4
Pages
e149
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
T2 mapping is a magnetic resonance imaging technique measuring T2 relaxation time, which increases with the myocardial tissue water content. Myocardial edema is a component of acute cellular rejection (ACR) after heart transplantation. This pilot study compares in heart transplantation recipients a novel high resolution 3-dimensional (3D) T2-mapping technique with standard 2-dimensional (2D) T2-mapping for ACR detection.
Consecutive asymptomatic patients (n = 26) underwent both 3D T2 mapping and reference 2D T2 mapping magnetic resonance imaging on the day of endomyocardial biopsy (EMB). 3D T2 maps were obtained at an isotropic spatial resolution of 1.72 mm (voxel volume 5.1 mm(3)). 2D and 3D maps were matched anatomically, and maximum segmental T2 values were compared blinded to EMB results. In addition, all 3D T2 maps were rendered as 3D images and inspected for foci of T2 elevation.
T2 values of segments from 2D and reformatted 3D T2 maps agreed (p > 0.5). The highest 2D segmental T2 values were 49.9 ± 4.0 ms (no ACR = 0R, n = 18), 48.9 ± 0.8 ms (mild ACR = 1R, n = 3), and 65.0 ms (moderate ACR = 2R). Rendered 3D T2 maps of cases with 1R showed foci with significantly elevated T2 signal (T2 = 58.2 ± 3.6 ms); 5 cases (28%) in the 0R group showed foci with increased T2 values (>2 SD above adjacent tissue) that were not visible on the 2D T2 maps.
This pilot study in a small cohort suggests equivalency of standard segmental analysis between 3D and 2D T2-mapping. 3D T2 mapping provides a spatial resolution that permits detection of foci with elevated T2 in patients with mild ACR.

Pubmed
Web of science
Open Access
Oui
Création de la notice
20/04/2017 8:49
Dernière modification de la notice
08/05/2019 22:12
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