VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones
Details
Serval ID
serval:BIB_93F5DB04C786
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones
Journal
European Journal of Neuroscience
ISSN
0953-816X
Publication state
Published
Issued date
01/1998
Peer-reviewed
Oui
Volume
10
Number
1
Pages
272-80
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
In view of the neurotrophic effect of vasoactive intestinal peptide (VIP), the regulation of brain-derived neurotrophic factor (BDNF) expression by VIP and the related peptide pituitary adenylate cyclase-activating polypeptide (PACAP) was analysed by Northern blot in primary cultures of cortical neurones. Results reported in this article demonstrate that VIP and PACAP stimulate the expression of BDNF mRNA in primary cultures of cortical neurones and astrocytes. In primary cultures of cortical neurones, induction of BDNF mRNA by VIP and PACAP is completely inhibited by the N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and AP5, therefore indicating that VIP and PACAP do not stimulate BDNF expression directly but rather by potentiating the effect of glutamate tonically released by neurones and acting at NMDA receptors. In addition to its neurotrophic effects, BDNF has been shown to be involved in neuronal plasticity and results reported here suggest that by stimulating BDNF expression, VIP and PACAP could modulate synaptic plasticity in the cerebral cortex.
Keywords
2-Amino-5-phosphonovalerate/pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
Alanine/analogs & derivatives/pharmacology
Animals
Astrocytes/cytology
Blotting, Northern
Brain-Derived Neurotrophic Factor/genetics
Cells, Cultured
Cerebral Cortex/*cytology
Dizocilpine Maleate/pharmacology
Drug Synergism
Excitatory Amino Acid Antagonists/pharmacology
Gene Expression/drug effects
Glutamic Acid/*pharmacology
Mice
Neuronal Plasticity/drug effects/physiology
Neurons/chemistry/cytology/drug effects
Neuropeptides/*pharmacology
Neurotransmitter Agents/*pharmacology
Pituitary Adenylate Cyclase-Activating Polypeptide
RNA, Messenger/analysis
Receptors, N-Methyl-D-Aspartate/physiology
Vasoactive Intestinal Peptide/*pharmacology
Pubmed
Web of science
Create date
20/01/2008 19:22
Last modification date
20/08/2019 15:56