Sgk kinases and their role in epithelial transport

Détails

ID Serval
serval:BIB_93F3FED16A72
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Sgk kinases and their role in epithelial transport
Périodique
Annual Review of Physiology
Auteur(s)
Loffing  J., Flores  S. Y., Staub  O.
ISSN
0066-4278 (Print)
Statut éditorial
Publié
Date de publication
2006
Volume
68
Pages
461-90
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Résumé
The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the regulation of epithelial ion transport. This kinase is very rapidly regulated at the transcriptional level as well as via posttranslational modifications involving phosphorylation by the MAP or PI-3 kinase pathways and/or ubiquitylation. Although Sgk1 is a cell survival kinase, its primary role likely concerns the regulation of epithelial ion transport, as suggested by the phenotype of Sgk1-null mice, which display a defect in Na( homeostasis owing to disturbed renal tubular Na+ handling. In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport.
Mots-clé
Animals Biological Transport, Active/genetics/*physiology Epithelium/*metabolism Humans Immediate-Early Proteins/genetics/metabolism/*physiology Isoenzymes/metabolism/physiology Mice Protein-Serine-Threonine Kinases/genetics/metabolism/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 14:03
Dernière modification de la notice
03/03/2018 19:36
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