Effect of propofol on cerebrospinal fluid pressure and cerebral perfusion pressure in patients undergoing craniotomy

Détails

ID Serval
serval:BIB_93ED64D8A018
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of propofol on cerebrospinal fluid pressure and cerebral perfusion pressure in patients undergoing craniotomy
Périodique
Anaesthesia
Auteur(s)
Ravussin  P., Guinard  J. P., Ralley  F., Thorin  D.
ISSN
0003-2409
Statut éditorial
Publié
Date de publication
03/1988
Peer-reviewed
Oui
Volume
43 Suppl
Pages
37-41
Notes
Journal Article --- Old month value: Mar
Résumé
The effects of propofol on cerebrospinal fluid pressure, mean arterial pressure, cerebral perfusion pressure and heart rate were studied during induction, tracheal intubation and skin incision in 23 patients scheduled for elective craniotomy. Premedication consisted of midazolam 0.1 mg/kg intramuscularly and metoprolol 1 mg/kg orally. Measurements were made or derived at time zero and 0.5, 1, 1.5, 2 and 3 minutes after an induction dose of propofol 1.5 mg/kg. A continuous infusion of propofol was started at time zero at a rate of 100 mg/kg/minute. Fentanyl 2 micrograms/kg was added before tracheal intubation, application of the pin head holder and skin incision. Cerebrospinal fluid pressure and mean arterial pressure decreased significantly 2 minutes after propofol alone, by 32% and 10% respectively, while a cerebral perfusion pressure above 70 mmHg was maintained. Heart rate did not change. Propofol combined with moderate dose of fentanyl, obtunded the usual cerebrospinal fluid and arterial pressure responses to intubation and other noxious stimuli. Thus propofol seems to be a suitable intravenous anaesthetic agent for induction and maintenance in neuroanaesthesia.
Mots-clé
Anesthesia, Intravenous Anesthetics/*pharmacology Blood Pressure/drug effects Cerebrovascular Circulation/*drug effects *Craniotomy Drug Evaluation Humans Intracranial Pressure/*drug effects Middle Aged Phenols/*pharmacology Propofol Time Factors
Pubmed
Web of science
Création de la notice
17/01/2008 17:19
Dernière modification de la notice
03/03/2018 19:36
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